Ebrahimi Katayoon B, Oster Stephen F, Green W Richard, Grebe Rhonda, Schein Oliver D, Jun Albert S
Eye Pathology Laboratory, Wilmer Eye Institute, The Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA.
Cornea. 2009 Apr;28(3):342-4. doi: 10.1097/ICO.0b013e3181861c98.
To report a case of host-donor interface calcification after Descemet membrane stripping with automated endothelial keratoplasty (DSAEK).
Review of the patient's clinical records and histopathologic examination of the donor corneal lamella from repeat DSAEK performed subsequent to the original DSAEK.
Review of the clinical record of the patient revealed an ocular history of Fuchs dystrophy and pseudophakic bullous keratoplasty that was treated with DSAEK. She later developed corneal edema and a partially detached donor lamella and underwent repeat DSAEK. Histopathologic and transmission electron microscopic evaluations of the corneal lamella revealed calcium deposits in the host-donor interface.
Calcareous degeneration of the host-donor interface after DSAEK is reported as a novel postoperative complication of DSAEK. Calcium deposits in the host-donor interface after DSAEK should be considered in the differential diagnosis of interface opacity after this procedure, particularly in patients with predisposing systemic or local risk factors such as retained phosphate-containing viscoelastic material, excessive postoperative inflammation, or use of phosphate-buffered, postoperative topical medications.
报告1例在使用自动角膜内皮移植术（DSAEK）进行后弹力层剥除术后出现宿主-供体界面钙化的病例。
回顾患者的临床记录，并对初次DSAEK术后再次行DSAEK时获取的供体角膜片进行组织病理学检查。
回顾患者的临床记录发现其有Fuchs角膜内皮营养不良和人工晶状体植入术后大泡性角膜病变的眼部病史，均接受了DSAEK治疗。她后来出现角膜水肿和部分供体植片脱离，并接受了再次DSAEK。对角膜片进行组织病理学和透射电子显微镜评估发现宿主-供体界面有钙沉积。
DSAEK术后宿主-供体界面的钙质变性被报告为DSAEK一种新的术后并发症。在该手术术后界面混浊的鉴别诊断中，应考虑DSAEK术后宿主-供体界面的钙沉积，尤其是对于有易患性全身或局部危险因素的患者，如残留含磷酸盐的粘弹剂、术后炎症过度或使用磷酸盐缓冲的术后局部用药。
