塞来昔布联合奥沙利铂对肿瘤生长的协同抑制作用。
Synergistic inhibition effect of tumor growth by using celecoxib in combination with oxaliplatin.
作者信息
Zhao Shipeng, Cai Jianhui, Bian Honglei, Gui Lin, Zhao Fa
机构信息
Department of Coloproctology, Third Hospital of Hebei Medical University, Shijiazhuang HeBei, China.
出版信息
Cancer Invest. 2009 Jul;27(6):636-40. doi: 10.1080/07357900802672738.
BACKGROUND
To evaluate the effects of celecoxib, in combination with oxaliplatin, on tumour growth, cell apoptosis and angiogenesis in nude mice models.
MATERIALS AND METHODS
Xenograft mice model of colon cancer was established using the BALB/c nude mice. Medicine was administered respectively in different groups. Tumour volumes, the expression level of survivin, beta-catenin, VEGF mRNA level, the microvessel density and cell apoptosis were measured.
RESULTS
Celecoxib, oxaliplatin and combination use caused a tumour inhibition of 35%, 31% and 63% respectively. Compared with control group, a significant redation of angiogenesis and the levels of COX-2, survivin and beta-cantenin protein, and increase of cell apoptosis were detected in tumors in celecoxib group. Celecoxib in combination with oxaliplatin could further promote cell apoptosis and reduce beta-catenin protein expression.
CONCLUSION
Celecoxib could inhibit tumor growth and enhance the antitumor effects of oxaliplatin through their synergistic role in inhibiting different targets.
背景
评估塞来昔布联合奥沙利铂对裸鼠模型中肿瘤生长、细胞凋亡和血管生成的影响。
材料与方法
使用BALB/c裸鼠建立结肠癌异种移植小鼠模型。在不同组中分别给药。测量肿瘤体积、生存素、β-连环蛋白的表达水平、VEGF mRNA水平、微血管密度和细胞凋亡情况。
结果
塞来昔布、奥沙利铂及联合使用分别导致肿瘤抑制率为35%、31%和63%。与对照组相比，塞来昔布组肿瘤中血管生成以及COX-2、生存素和β-连环蛋白蛋白水平显著降低，细胞凋亡增加。塞来昔布与奥沙利铂联合可进一步促进细胞凋亡并降低β-连环蛋白蛋白表达。
结论
塞来昔布可通过其在抑制不同靶点中的协同作用抑制肿瘤生长并增强奥沙利铂的抗肿瘤作用。
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