作为凝集素配体的氟化碳水化合物：¹⁹F检测的饱和转移差异核磁共振波谱中的多功能传感器。

Fluorinated carbohydrates as lectin ligands: versatile sensors in 19F-detected saturation transfer difference NMR spectroscopy.

作者信息

Diercks Tammo, Ribeiro João P, Cañada F Javier, André Sabine, Jiménez-Barbero Jesús, Gabius Hans-Joachim

机构信息

NMR facility, CiC bioGUNE, Parque Tecnológico de Bizkaia, Ed. 800, 48160 Derio, Spain.

出版信息

Chemistry. 2009 Jun 2;15(23):5666-8. doi: 10.1002/chem.200900168.

DOI:10.1002/chem.200900168

PMID:19388026

Abstract

As a novel approach for studying carbohydrate-lectin interactions spectroscopically, we combine the resolution and specificity of (19)F-detected NMR spectroscopy with the sensitivity of the saturation transfer difference (STD) technique. The resulting background-free (19)F-STD spectra open a promising perspective for broad application with medical relevance, for example, in drug discovery.

摘要

作为一种通过光谱学研究碳水化合物-凝集素相互作用的新方法，我们将（19）F检测的核磁共振光谱的分辨率和特异性与饱和转移差异（STD）技术的灵敏度相结合。由此产生的无背景（19）F-STD光谱为与医学相关的广泛应用，例如在药物发现中，开辟了一个有前景的前景。