Carroll Michael C
Immune Disease Institute, Harvard Medical School, 800 Huntington Avenue, Boston, MA 02115, United States.
Vaccine. 2008 Dec 30;26 Suppl 8(0 8):I28-33. doi: 10.1016/j.vaccine.2008.11.022.
The complement system was discovered almost a century ago as an important effector in antibody-dependent killing of microorganisms. Since this early period much was learned aboutthe biochemistry and structure of complement proteins and their function in mediating inflammation. More recently, a prominent role for complement was identified in linkage of innate and adaptive immunity. In this review, I will discuss our current understanding of the importance of complement in enhancing the humoral immune response to both model antigens and pathogens. As discussed below, it is evident that the complement system participates in marking of "foreign" pathogens and "presenting" them to B cells in a manner that enhances both antibody production and long-term memory. In this special issue of Vaccine, we see examples of how complement is critical in the immune response to bacterial and viral pathogens. Moreover, the finding that most organisms have co-evolved proteins to evade complement detection underscores its importance in host protection.
补体系统大约在一个世纪前被发现，是抗体依赖性杀灭微生物的重要效应物。自早期以来，人们对补体蛋白的生物化学、结构及其在介导炎症中的功能有了很多了解。最近，补体在先天免疫和适应性免疫的联系中被确定发挥重要作用。在这篇综述中，我将讨论我们目前对补体在增强对模型抗原和病原体的体液免疫反应中的重要性的理解。如下所述，很明显补体系统参与标记“外来”病原体，并以增强抗体产生和长期记忆的方式将它们“呈递”给B细胞。在本期《疫苗》特刊中，我们看到了补体在对细菌和病毒病原体的免疫反应中至关重要的例子。此外，大多数生物体已经共同进化出蛋白质以逃避补体检测这一发现凸显了补体在宿主保护中的重要性。
