Department of Ophthalmology, Keio University School of Medicine, Shinanomachi 35, Shinjuku-ku, Tokyo, Japan.
Biol Trace Elem Res. 2009 Dec;132(1-3):1-8. doi: 10.1007/s12011-009-8376-z.
We evaluated the association between hair lead concentrations and primary open-angle glaucoma. Ninety-eight Japanese patients (40 males, 58 females; average age 57.6 ± 10.8 years) with primary open-angle glaucoma and control subjects (131 males, 114 females; average age 56.0 ± 12.8 years) were recruited in this study. Hair lead levels were measured by inductively coupled plasma mass spectrometry. Hair lead concentrations between primary open-angle glaucoma and control groups were compared using Mann-Whitney U test. As a subgroup analysis, we compared hair lead concentrations between low-tension glaucoma, high-tension glaucoma, and control groups using one-factor analysis of variance. Lead accumulation levels were significantly higher in the female subjects with primary open-angle glaucoma compared to the control group (P=0.03). Lead accumulation levels were significantly higher in female patients with low intraocular pressure compared to control group 2 (P=0.02). A higher hair lead level, which reflects the total body burden of lead, was observed to be associated with primary open-angle glaucoma in females especially with low-tension glaucoma. Accumulation of lead may be an unrecognized risk factor of non-pressure-dependent glaucomatous optic neuropathy.
我们评估了头发铅浓度与原发性开角型青光眼之间的关系。本研究纳入了 98 例原发性开角型青光眼患者（男性 40 例，女性 58 例；平均年龄 57.6±10.8 岁）和对照组患者（男性 131 例，女性 114 例；平均年龄 56.0±12.8 岁）。采用电感耦合等离子体质谱法测定头发铅水平。采用曼-惠特尼 U 检验比较原发性开角型青光眼组和对照组的头发铅浓度。作为亚组分析，我们采用单因素方差分析比较低眼压性青光眼、高眼压性青光眼和对照组之间的头发铅浓度。与对照组相比，女性原发性开角型青光眼患者的铅蓄积水平显著升高（P=0.03）。与对照组 2 相比，女性低眼压患者的铅蓄积水平显著升高（P=0.02）。较高的头发铅水平反映了体内铅的总负荷，与女性尤其是低眼压性原发性开角型青光眼有关。铅的蓄积可能是一种未被认识的非压力依赖性青光眼性视神经病变的危险因素。
