Ponampalam R, Tan Hock Heng, Ng Kee Chong, Lee Wee Yee, Tan Sau Chew
Department of Emergency Medicine, Singapore General Hospital, Singapore. Singapore.
Int J Emerg Med. 2009 Apr;2(1):25-31. doi: 10.1007/s12245-008-0080-9. Epub 2009 Feb 4.
The demographics of poisoned patients and the circumstances of toxic exposure have not been evaluated in Singapore for the last 10 years.
This study aims to give an estimate of the burden of poisoning in Singapore from the emergency department's (ED) perspective.
A retrospective study of toxic exposure was conducted over a period of 3 years from 2001 to 2003 at the ED of three public hospitals, one being a paediatric hospital.
There were 9,212 cases of toxic exposures during the study period, which constituted 0.94% of total ED attendances. The poison exposure rate was 1.7 per 1,000 population and the estimated case fatality rate was 0.8 per 1,000 ED attendances for poisoning. The mean age of patients was 29 years and the majority were male (63.3%). Non-accidental injuries constituted 60% of the cohort. Alcohol was the commonest toxin involved (26%), but paracetamol (acetaminophen) was the most common pharmaceutical agent (33%). The mean time of exposure to ED presentation was 3.3 h. About one third of the patients were admitted of whom 157 patients (4.7% of admitted cases) required intensive care management.
The patients were predominantly young adults. This may suggest a need for poison prevention and chemical safety education to reduce the impact on this high-risk group. Although poisoning accounts for only 1% of the total ED attendance, a sizable proportion of them required inpatient care (36.1%) with a significant proportion requiring intensive care management. However, it was also noted that a third of those who were admitted stayed for less than 24 h, and hence a short-stay ward in the ED might be a cost-effective strategy to consider.
过去10年新加坡尚未对中毒患者的人口统计学特征及中毒暴露情况进行评估。
本研究旨在从急诊科角度估算新加坡中毒负担。
2001年至2003年期间,在三家公立医院(其中一家为儿科医院)的急诊科进行了一项中毒暴露回顾性研究。
研究期间共发生9212例中毒暴露病例,占急诊科就诊总数的0.94%。中毒暴露率为每1000人中有1.7例,中毒的估计病死率为每1000例急诊科就诊中有0.8例。患者的平均年龄为29岁,大多数为男性(63.3%)。非意外伤害占该队列的60%。酒精是最常见的中毒物质(26%),但对乙酰氨基酚是最常见的药物(33%)。从暴露到急诊科就诊的平均时间为3.3小时。约三分之一的患者入院,其中157例患者(占入院病例的4.7%)需要重症监护管理。
患者主要为年轻人。这可能表明需要进行中毒预防和化学品安全教育,以减少对这一高危群体的影响。尽管中毒仅占急诊科就诊总数的1%,但其中相当一部分患者需要住院治疗(36.1%),且有相当比例的患者需要重症监护管理。然而,也注意到三分之一的入院患者住院时间不足24小时,因此急诊科的短期病房可能是一种值得考虑的具有成本效益的策略。