Yoshikawa Takaki, Cho Haruhiko, Tsuburaya Akira, Kobayashi Osamu
Department of Gastrointestinal Surgery, Kanagawa Cancer Center, 1-1-2 Nakao, Asahi-ku, Yokohama, 241-0815, Japan.
Gastric Cancer. 2009;12(1):31-6. doi: 10.1007/s10120-008-0494-3. Epub 2009 Apr 24.
The expression of tissue inhibitor of metalloproteinase-1 (TIMP-1) is correlated with tumor invasion and metastases.
The plasma TIMP-1 concentration was examined preoperatively in 149 patients with gastric cancer who underwent a surgical resection. The cutoff value of TIMP-1 was set at 112.5 ng/ml based on a previous report. These patients were followed up for more than 5 years prospectively.
Plasma TIMP-1 was positive in 30 of the 149 patients (20.1%). The overall survival rate was 78.2% at 5 years in patients with negative plasma TIMP-1, while this rate was 26.7% at 5 years in patients with positive plasma TIMP-1. By univariate analyses, T, N, M, and R category, and TIMP-1, were significant prognosticators. Multivariate analyses demonstrated T, N, and TIMP-1 to be significant prognosticators. The survival curve was clearly separated with respect to TIMP-1.
These results suggest that plasma TIMP-1 is a strong independent prognosticator for the long-term survival of patients with gastric cancer.
金属蛋白酶组织抑制剂-1（TIMP-1）的表达与肿瘤侵袭和转移相关。
对149例行手术切除的胃癌患者术前检测血浆TIMP-1浓度。根据先前报道，将TIMP-1的临界值设定为112.5 ng/ml。对这些患者进行了超过5年的前瞻性随访。
149例患者中有30例（20.1%）血浆TIMP-1呈阳性。血浆TIMP-1阴性患者的5年总生存率为78.2%，而血浆TIMP-1阳性患者的5年总生存率为26.7%。单因素分析显示，T、N、M和R分类以及TIMP-1是显著的预后因素。多因素分析表明，T、N和TIMP-1是显著的预后因素。生存曲线在TIMP-1方面有明显分离。
这些结果表明，血浆TIMP-1是胃癌患者长期生存的强有力独立预后因素。
