Yukawa Norio, Yoshikawa Takaki, Akaike Makoto, Sugimasa Yukio, Rino Yasushi, Masuda Munetaka, Imada Toshio
Department of Surgery, Yokohama City University, Yokohama, Japan.
Oncology. 2007;72(3-4):205-8. doi: 10.1159/000112827. Epub 2007 Dec 21.
Tissue inhibitor of metalloproteinase-1 (TIMP-1) not only inhibits matrix metalloproteinases but also stimulates tumor growth. In this study, long-term follow-up results were analyzed to clarify the prognostic value of plasma TIMP-1. Preoperative plasma TIMP-1 was measured from peripheral blood samples of 87 Japanese patients with colorectal carcinoma. All the patients underwent surgical resection and were followed for 5 years prospectively. The median follow-up period was 70 months (60-79 months). The cutoff value of plasma TIMP-1 was set at 170 ng/ml based on the ROC curve. Sensitivity and specificity to predict 5-year survival was 66.7 and 55.0% with this cutoff value. In univariate analyses for overall survival, lymph node metastasis, serosal invasion, peritoneal metastasis, liver metastasis, metastasis to other distant organs and TIMP-1 were significant. In multivariate analyses, lymph node and liver metastases, metastasis to other distant organs and plasma TIMP-1 were independent prognosticators, but p values of TIMP-1 did not reach statistical significance. Our results suggested that the preoperative plasma TIMP-1 concentration could be a useful prognosticator of long-term survival in patients with colorectal carcinoma.
金属蛋白酶组织抑制剂-1（TIMP-1）不仅能抑制基质金属蛋白酶，还能刺激肿瘤生长。在本研究中，分析了长期随访结果以阐明血浆TIMP-1的预后价值。从87例日本结直肠癌患者的外周血样本中检测术前血浆TIMP-1。所有患者均接受手术切除，并进行了5年的前瞻性随访。中位随访期为70个月（60-79个月）。根据ROC曲线，将血浆TIMP-1的临界值设定为170 ng/ml。以此临界值预测5年生存率的敏感性和特异性分别为66.7%和55.0%。在总生存的单因素分析中，淋巴结转移、浆膜侵犯、腹膜转移、肝转移、其他远处器官转移和TIMP-1具有显著性。在多因素分析中，淋巴结和肝转移、其他远处器官转移及血浆TIMP-1是独立的预后因素，但TIMP-1的p值未达到统计学显著性。我们的结果表明，术前血浆TIMP-1浓度可能是结直肠癌患者长期生存的有用预后指标。
