Berdeli Afig, Cam F Sirri
Molecular Medicine Laboratory, Department of Pediatrics, Faculty of Medicine, Ege University, Izmir, Turkey.
Biochem Genet. 2009 Jun;47(5-6):412-20. doi: 10.1007/s10528-009-9240-8. Epub 2009 Apr 24.
Angiotensin converting enzyme (ACE) plays an essential role in the renin-angiotensin system. It converts angiotensin I to angiotensin II and inactivates bradykinin and tachykinins. Numerous studies have been published investigating associations of the ACE gene I/D polymorphism with various pathophysiological conditions. We examined the prevalence of the ACE I/D polymorphism in a sample of healthy volunteers from western Turkey, including 1063 healthy Turkish controls. Analysis of the ACE I/D gene polymorphisms by polymerase chain reaction found frequencies of 16.1% for the II genotype, 47.7% for the ID genotype, and 36.2% for the DD genotype. The allele frequency was 39.9% for the I alleles and 60.1% for the D allele. This study demonstrates that the allele and genotype frequency values for the Turkish population are similar to previously published frequencies for Caucasian populations.
血管紧张素转换酶（ACE）在肾素-血管紧张素系统中起着至关重要的作用。它将血管紧张素I转化为血管紧张素II，并使缓激肽和速激肽失活。已经发表了许多研究，探讨ACE基因I/D多态性与各种病理生理状况之间的关联。我们在来自土耳其西部的健康志愿者样本中检查了ACE I/D多态性的患病率，其中包括1063名健康的土耳其对照。通过聚合酶链反应分析ACE I/D基因多态性发现，II基因型的频率为16.1%，ID基因型的频率为47.7%，DD基因型的频率为36.2%。I等位基因的频率为39.9%，D等位基因的频率为60.1%。这项研究表明，土耳其人群的等位基因和基因型频率值与先前发表的高加索人群的频率相似。
