土耳其阻塞性睡眠呼吸暂停综合征患者血管紧张素转换酶插入/缺失多态性与血清活性。
Insertion/deletion polymorphism and serum activity of the angiotensin-converting enzyme in Turkish patients with obstructive sleep apnea syndrome.
机构信息
Department of Chest Diseases, Akdeniz University, Antalya, Turkey.
出版信息
Biochem Genet. 2010 Jun;48(5-6):516-23. doi: 10.1007/s10528-010-9335-2. Epub 2010 Feb 25.
This study determined the allelic frequency and genotypic distribution of an angiotensin-converting enzyme (ACE) polymorphism and serum ACE activity in Turkish patients with obstructive sleep apnea syndrome (OSAS). A colorimetric assay measured serum ACE activity in 73 of 97 subjects. Frequencies for II, ID, and DD genotypes were 19.6, 53.6, and 26.8% in the OSAS group and 15, 38, and 47% in the control group, respectively (P = 0.02). The I allele frequency was higher in the OSAS group than in the healthy control group (P = 0.02). Carrying the I allele (II or ID genotypes) increased OSAS risk 2.41 times in the Turkish population. Mean ACE activity was significantly lower in patients with the II genotype than in the DD genotype (P = 0.011), and ACE activity was significantly lower in patients with severe OSAS than in those with mild OSAS (P = 0.006). Our results suggest that II and ID genotypes of the ACE gene increase the risk of developing OSAS in the Turkish population.
本研究旨在确定土耳其阻塞性睡眠呼吸暂停综合征（OSAS）患者血管紧张素转换酶（ACE）多态性的等位基因频率和基因型分布以及血清 ACE 活性。在 97 名受试者中的 73 名中使用比色法测定血清 ACE 活性。OSAS 组的 II、ID 和 DD 基因型频率分别为 19.6%、53.6%和 26.8%，对照组分别为 15%、38%和 47%（P=0.02）。OSAS 组的 I 等位基因频率高于健康对照组（P=0.02）。在土耳其人群中，携带 I 等位基因（II 或 ID 基因型）使 OSAS 风险增加 2.41 倍。与 DD 基因型相比，II 基因型患者的 ACE 活性显著降低（P=0.011），且重度 OSAS 患者的 ACE 活性显著低于轻度 OSAS 患者（P=0.006）。我们的研究结果表明，ACE 基因的 II 和 ID 基因型增加了土耳其人群患 OSAS 的风险。
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