Department of Surgery, University of Texas Health Science Center at Houston, 6431 Fannin Street, Suite 4.264, Houston, TX, 77030, USA.
Dig Dis Sci. 2010 Apr;55(4):902-10. doi: 10.1007/s10620-009-0800-x. Epub 2009 Apr 24.
Lipopolysaccharide (LPS) increases systemic inflammation and causes duodenogastric reflux of bile and gastric bleeding. Laparotomy prevents gastric injury from the luminal irritant bile, but its effects on LPS-induced gastric injury are unknown. We hypothesized that laparotomy would diminish inflammation and attenuate gastric bleeding caused by LPS. In the rat, laparotomy, done either before or after administration of LPS, attenuated LPS-induced bile reflux, gastric bleeding, and cyclooxygenase-2, but not inducible nitric oxide synthase, expression when compared to controls given LPS. Laparotomy also blunted LPS-induced changes in serum cytokine production. These data suggest that laparotomy has gastroprotective effects by preventing LPS-induced bile reflux and gastric bleeding and by a mechanism mediated, at least in part by cyclooxygenase-2.
脂多糖（LPS）会增加全身炎症，并导致胆汁十二指肠胃反流和胃出血。剖腹术可防止腔内刺激性胆汁引起的胃损伤，但它对 LPS 诱导的胃损伤的影响尚不清楚。我们假设剖腹术会减轻 LPS 引起的炎症并减轻胃出血。在大鼠中，与给予 LPS 的对照组相比，剖腹术无论是在 LPS 给药之前还是之后进行，均可减轻 LPS 引起的胆汁反流、胃出血和环加氧酶-2，但不减轻诱导型一氧化氮合酶的表达。剖腹术还可减轻 LPS 引起的血清细胞因子产生的变化。这些数据表明，剖腹术具有胃保护作用，可通过防止 LPS 诱导的胆汁反流和胃出血来实现，其机制至少部分通过环加氧酶-2来介导。
