具有 pH 和温度敏感性基团的超支化聚（缩水甘油）的合成与表征。

Synthesis and characterization of hyperbranched poly(glycidol) modified with pH- and temperature-sensitive groups.

机构信息

Department of Applied Chemistry, Osaka Prefecture University, Osaka, Japan.

出版信息

Bioconjug Chem. 2009 May 20;20(5):1054-7. doi: 10.1021/bc900016x.

PMID:19391618

Abstract

Hyperbranched poly(glycidol)s with varying degrees of polymerization were modified by reaction with succinic anhydride and isopropylamine to obtain novel pH- and thermosensitive polymers. These polymers exhibited phase transitions in response to decreasing pH and/or increasing temperature, depending on the degree of polymerization and the ratio of succinyl group to N-isopropylamide. It was possible to harvest a bioactive molecule, rose bengal, from solution using the phase transition of thermosensitive hyperbranched poly(glycidol).

摘要

超支化聚（缩水甘油）的聚合度不同，通过与琥珀酸酐和异丙胺反应进行修饰，得到了新型的 pH 值和温度敏感聚合物。这些聚合物根据聚合度和琥珀酰基与 N-异丙基酰胺的比例，在 pH 值降低和/或温度升高时发生相转变。可以使用热敏超支化聚（缩水甘油）的相转变从溶液中收获生物活性分子孟加拉玫瑰红。