Schulze Agnes, Went Marco, Prager Andrea
Leibniz Institute of Surface Functionalization, Permoserstr. 15, Leipzig D-04318, Germany.
Materials (Basel). 2016 Aug 20;9(8):706. doi: 10.3390/ma9080706.
Polymer membranes have been modified with hyperbranched polymers with the aim to generate a high density of hydrophilic functional groups at the membrane surface. For this purpose hyperbranched polymers containing amino, alcohol, and carboxylic acid end groups were used for membrane modification, respectively. Thus, surface potential and charges were changed significantly to result in attractive or repulsive interactions towards three different proteins (albumin, lysozyme, myoglobin) that were used to indicate membrane fouling properties. Our studies demonstrated that hydrophilization alone is not effective for avoiding membrane fouling when charged proteins are present. In contrast, electrostatic repulsion seems to be a general key factor.
为了在膜表面产生高密度的亲水性官能团，人们用超支化聚合物对聚合物膜进行了改性。为此，分别使用了含有氨基、醇基和羧酸端基的超支化聚合物对膜进行改性。因此，表面电位和电荷发生了显著变化，从而导致与三种不同蛋白质（白蛋白、溶菌酶、肌红蛋白）产生吸引或排斥相互作用，这些蛋白质被用来指示膜的污染特性。我们的研究表明，当存在带电蛋白质时，仅靠亲水化对于避免膜污染是无效的。相反，静电排斥似乎是一个普遍的关键因素。
