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本文引用的文献

1
High-resolution donor-recipient HLA matching contributes to the success of unrelated donor marrow transplantation.高分辨率的供受者人类白细胞抗原（HLA）配型有助于无关供者骨髓移植的成功。
Blood. 2007 Dec 15;110(13):4576-83. doi: 10.1182/blood-2007-06-097386. Epub 2007 Sep 4.
2
The nature of diversity of HLA-DRB1 exon 3.
Tissue Antigens. 2007 Oct;70(4):335-7. doi: 10.1111/j.1399-0039.2007.00918.x.
3
A high degree of HLA disparity arises from limited allelic diversity: analysis of 1775 unrelated bone marrow transplant donor-recipient pairs.高度的人类白细胞抗原（HLA）差异源于有限的等位基因多样性：对1775对无关骨髓移植供受者配对的分析
Hum Immunol. 2007 Jan;68(1):30-40. doi: 10.1016/j.humimm.2006.09.004. Epub 2006 Oct 25.
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Searching for HLA-DRB1*1206 in volunteer marrow donors in four US population groups.在美国四个群体的志愿骨髓捐献者中寻找HLA-DRB1*1206。
Tissue Antigens. 2006 Nov;68(5):439-41. doi: 10.1111/j.1399-0039.2006.00689.x.
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The Amber biomolecular simulation programs.琥珀生物分子模拟程序。
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Structure of a complex of the human alpha/beta T cell receptor (TCR) HA1.7, influenza hemagglutinin peptide, and major histocompatibility complex class II molecule, HLA-DR4 (DRA*0101 and DRB1*0401): insight into TCR cross-restriction and alloreactivity.人α/β T细胞受体（TCR）HA1.7、流感血凝素肽与主要组织相容性复合体II类分子HLA-DR4（DRA*0101和DRB1*0401）复合物的结构：对TCR交叉限制和同种异体反应性的深入了解
J Exp Med. 2002 Mar 4;195(5):571-81. doi: 10.1084/jem.20011194.
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Crystal structure of the human CD4 N-terminal two-domain fragment complexed to a class II MHC molecule.与II类主要组织相容性复合体分子复合的人CD4 N端双结构域片段的晶体结构。
Proc Natl Acad Sci U S A. 2001 Sep 11;98(19):10799-804. doi: 10.1073/pnas.191124098. Epub 2001 Sep 4.
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Comparative protein structure modeling of genes and genomes.基因与基因组的比较蛋白质结构建模
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9
The different level of expression of HLA-DRB1 and -DRB3 genes is controlled by conserved isotypic differences in promoter sequence.HLA - DRB1和 - DRB3基因不同水平的表达受启动子序列中保守的同种型差异控制。
Hum Immunol. 1993 Oct;38(2):137-47. doi: 10.1016/0198-8859(93)90531-5.

评估无关造血干细胞移植中抗原识别位点以外错配的潜在影响：HLA-DRB1*1454和DRB1*140101。

Evaluating the potential impact of mismatches outside the antigen recognition site in unrelated hematopoietic stem cell transplantation: HLA-DRB1*1454 and DRB1*140101.

作者信息

Xiao Y, Lazaro A M, Masaberg C, Haagenson M, Vierra-Green C, Spellman S, Dakshanamurthy S, Ng J, Hurley C K

机构信息

Department of Pediatrics and Oncology, C.W. Bill Young Marrow Donor Research and Recruitment Program, Georgetown University Medical Center, Washington, DC 20057, USA.

出版信息

Tissue Antigens. 2009 Jun;73(6):595-8. doi: 10.1111/j.1399-0039.2009.01245.x. Epub 2009 Apr 6.

DOI:10.1111/j.1399-0039.2009.01245.x
PMID:19392807
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3224974/
Abstract

DNA sequencing of 268 individuals drawn from four US populations carrying two unresolved DRB114 alleles differing only outside the antigen recognition site identified DRB11454 in the majority. A database of 4222 human leukocyte antigen (HLA)-matched hematopoietic stem cell transplantation donor-recipient pairs was queried to determine the number likely mismatched for DRB1140101/DRB11454 but matched for class I loci. A power calculation suggests that more than 88,000 transplants among European Americans will be needed to identify sufficient 7/8 allele-matched pairs to evaluate the impact of the DRB1140101/DRB11454 mismatch on transplant outcome. Molecular modeling of the HLA-DR interaction with the T-cell receptor and with CD4 suggests that the amino acid substitution distinguishing the two alleles will have minimal impact on allorecognition.

摘要

对来自美国四个群体的268名个体进行DNA测序，这些个体携带两个未解析的DRB114等位基因，它们仅在抗原识别位点之外存在差异，结果在大多数个体中鉴定出DRB11454。查询了一个由4222对人类白细胞抗原（HLA）匹配的造血干细胞移植供受者组成的数据库，以确定可能在DRB1140101/DRB11454上不匹配但在I类基因座上匹配的数量。一项功效计算表明，在美国白人中需要进行超过88,000例移植，才能识别出足够数量的7/8等位基因匹配对，以评估DRB1140101/DRB11454不匹配对移植结果的影响。HLA-DR与T细胞受体以及与CD4相互作用的分子模型表明，区分这两个等位基因的氨基酸取代对同种异体识别的影响极小。