利用遗传性视网膜变性犬模型来测试新型治疗方法。
The use of canine models of inherited retinal degeneration to test novel therapeutic approaches.
作者信息
Beltran William A
机构信息
Section of Ophthalmology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, USA.
出版信息
Vet Ophthalmol. 2009 May-Jun;12(3):192-204. doi: 10.1111/j.1463-5224.2009.00694.x.
Abstract
Inherited retinal degenerations (RDs) are a common cause of blindness in dogs and in humans. Over the past two decades numerous genes causally associated with these diseases have been identified and several canine models have been used to improve our understanding of the molecular mechanisms of RDs, as well as to test the proof of principle and safety of novel therapies. This review briefly summarizes the drug delivery approaches and therapeutic strategies that have been and are currently tested in dogs, with a particular emphasis on corrective gene therapy, and retinal neuroprotection.
摘要
遗传性视网膜变性（RDs）是导致犬类和人类失明的常见原因。在过去二十年中，已鉴定出许多与这些疾病有因果关系的基因，并使用了几种犬类模型来增进我们对RDs分子机制的理解，以及测试新疗法的原理验证和安全性。本综述简要总结了过去和目前在犬类中测试的给药方法和治疗策略，特别强调了矫正基因治疗和视网膜神经保护。
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