胃肠道整合素（α4β7）与选择素配体的结合增强了沙眼衣原体感染期间 T 细胞向生殖道的迁移。
The combination of the gastrointestinal integrin (α4β7) and selectin ligand enhances T-Cell migration to the reproductive tract during infection with Chlamydia trachomatis.
机构信息
Department of Pathology & Laboratory Medicine, Geffen School of Medicine, University of California, Los Angeles, CA 90095-1732, USA.
出版信息
Am J Reprod Immunol. 2009 Jun;61(6):446-52. doi: 10.1111/j.1600-0897.2009.00705.x. Epub 2009 Apr 22.
Abstract
PROBLEM
Chlamydia trachomatis causes sexually transmitted infection and reproductive dysfunction worldwide. Identifying a population of endocervical T-cells to target in vaccine development is likely to enhance efficacy of a vaccine and reduce reproductive tract dysfunction.
METHOD OF STUDY
Endocervical samples were obtained from young women and flow cytometric analysis was used to identify lymphocytes that appeared in the genital tract in response to sexually transmitted bacterial infections caused by C. trachomatis.
RESULTS
Increased numbers of α4β7+CLA+ memory T-cells, a unique T-cell phenotype, were found in the endocervix of human female subjects infected with C. trachomatis.
CONCLUSION
A unique population of memory T lymphocytes expressing both α4β7 and CLA gain access to reproductive tract tissues during a sexually transmitted infection with C. trachomatis and should be considered in development of vaccines against sexually transmitted infections.
摘要
问题
沙眼衣原体可导致全球范围内的性传播感染和生殖功能障碍。鉴定出一个可作为疫苗开发目标的宫颈内 T 细胞群体，可能会提高疫苗的功效并减少生殖道功能障碍。
方法
从年轻女性中获得宫颈样本，并通过流式细胞术分析鉴定出在生殖道中因沙眼衣原体引起的性传播细菌感染而出现的淋巴细胞。
结果
在感染沙眼衣原体的女性受试者的宫颈中发现了大量的 α4β7+CLA+记忆 T 细胞，这是一种独特的 T 细胞表型。
结论
在感染沙眼衣原体时，一种表达α4β7 和 CLA 的独特记忆性 T 淋巴细胞群进入生殖道组织，在针对性传播感染的疫苗开发中应予以考虑。
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