Chalouhi Gihad Elias, Golfier François, Soignon Pauline, Massardier Jerome, Guastalla Jean-Paul, Trillet-Lenoir Veronique, Schott Anne-Marie, Raudrant Daniel
Université de Lyon, F-69622, Lyon, France.
Am J Obstet Gynecol. 2009 Jun;200(6):643.e1-6. doi: 10.1016/j.ajog.2009.03.011. Epub 2009 Apr 23.
We sought to review efficacy and toxicity of an 8-day methotrexate (MTX) regimen in the treatment of patients with low-risk gestational trophoblastic neoplasia (GTN) from the French Trophoblastic Disease Reference Center.
Between 1999 and 2006, 142 low-risk GTNs were diagnosed according to International Federation of Gynecology and Obstetrics (FIGO) criteria for GTN and to the FIGO scoring system. We report their characteristics, remission/resistance/recurrence rates, and treatment toxicity.
The 8-day MTX regimen achieved a 77.5% remission rate. All patients but 1 (99.9%) achieved remission and remained disease free until the time of analysis. Severe (grade 3 or 4) blood/bone marrow toxicity and metabolic/laboratory toxicity was noted in 4.2% of cases, of which 2 (1.4%) were grade 4.
For patients with GTN diagnosed according to FIGO criteria and considered low risk according to the FIGO scoring system, an 8-day MTX regimen is an adequate treatment associating a high rate of remission to a low rate of toxicity.
我们旨在回顾法国滋养细胞疾病参考中心采用8天甲氨蝶呤（MTX）方案治疗低危妊娠滋养细胞肿瘤（GTN）患者的疗效和毒性。
1999年至2006年间，根据国际妇产科联合会（FIGO）的GTN标准和FIGO评分系统诊断出142例低危GTN患者。我们报告了他们的特征、缓解/耐药/复发率以及治疗毒性。
8天MTX方案的缓解率为77.5%。除1例患者外，所有患者（99.9%）均实现缓解，直至分析时仍无疾病。4.2%的病例出现严重（3级或4级）血液/骨髓毒性和代谢/实验室毒性，其中2例（1.4%）为4级。
对于根据FIGO标准诊断且根据FIGO评分系统被视为低危的GTN患者，8天MTX方案是一种合适的治疗方法，缓解率高且毒性低。
