Simultaneous high performance liquid chromatographic determination of dapsone and monoacetyldapsone in human plasma and urine.
作者信息
Abuirjeie M A, Irshaid Y M, al-Hadidi H F, Rawashdeh N M
机构信息
Department of Medicinal Chemistry, Faculty of Pharmacy, Jordan University of Science and Technology, Irbid.
出版信息
J Clin Pharm Ther. 1991 Aug;16(4):247-55. doi: 10.1111/j.1365-2710.1991.tb00311.x.
Abstract
A rapid, specific and a one-stage protein precipitation method for simultaneous estimation of dapsone (DDS) and monoacetyldapsone (MAD) concentration in plasma and urine using high performance liquid chromatography (HPLC) is described. The applicability of the method for monitoring DDS and MAD blood levels in two different acetylator phenotype volunteers following the administration of 100-mg oral dose of DDS was shown. Cumulative urinary excretion of DDS and MAD were studied in the same volunteers.
摘要
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