采用高效液相色谱法同时分析氨苯砜和单乙酰氨苯砜：一种快速测定乙酰化代谢表型的方法。
Simultaneous analysis of dapsone and monoacetyldapsone employing high performance liquid chromatography: a rapid method for determination of acetylator phenotype.
作者信息
Carr K, Oates J A, Nies A S, Woosley R L
出版信息
Br J Clin Pharmacol. 1978 Nov;6(5):421-7. doi: 10.1111/j.1365-2125.1978.tb04606.x.
Abstract
1 A rapid, accurate and convenient technique for determination of acetylator phenotype of patients or subjects has not been available for routine clinical application. 2 An improved method for rapid and convenient determination of acetylator phenotype is described. 3 The plasma concentrations of dapsone (DDS) and monoacetyldapsone (MAD) were measured 3 h after a single oral 100 mg dose of dapsone using a specific and sensitive high performance liquid chromatographic assay. 4 The plasma concentration ratio of monoacetyldapsone to dapsone can accurately assess acetylator phenotype in patients or subjects. 5 The clinical applications for this method are discussed.
摘要
- 一种快速、准确且便捷的用于测定患者或受试者乙酰化代谢表型的技术尚未用于常规临床应用。2. 描述了一种用于快速便捷地测定乙酰化代谢表型的改进方法。3. 使用一种特异且灵敏的高效液相色谱分析法，在单次口服100毫克氨苯砜后3小时测量血浆中氨苯砜（DDS）和单乙酰氨苯砜（MAD）的浓度。4. 单乙酰氨苯砜与氨苯砜的血浆浓度比能够准确评估患者或受试者的乙酰化代谢表型。5. 讨论了该方法的临床应用。
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Simultaneous analysis of dapsone and monoacetyldapsone employing high performance liquid chromatography: a rapid method for determination of acetylator phenotype.采用高效液相色谱法同时分析氨苯砜和单乙酰氨苯砜：一种快速测定乙酰化代谢表型的方法。
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