呼出气冷凝物中的过氧化氢和pH值用于评估马的下呼吸道炎症。

Exhaled breath condensate hydrogen peroxide and pH for the assessment of lower airway inflammation in the horse.

作者信息

Duz M, Whittaker A G, Love S, Parkin T D H, Hughes K J

机构信息

Faculty of Veterinary Medicine, Weipers Centre for Equine Welfare, Institute of Comparative Medicine, University of Glasgow, Glasgow G61 1QH, United Kingdom.

出版信息

Res Vet Sci. 2009 Oct;87(2):307-12. doi: 10.1016/j.rvsc.2009.03.014. Epub 2009 Apr 24.

DOI:10.1016/j.rvsc.2009.03.014

PMID:19394059

Abstract

Measurement of hydrogen peroxide (H(2)O(2)) concentration and pH in exhaled breath condensate (EBC) is useful for detection and monitoring of asthma in humans. In contrast, limited information on the use of these parameters for the investigation of lower airway inflammation (LAI) is available for horses. Aims of the current study were to investigate the intra- and inter-day variations of EBC H(2)O(2) concentration and pH in horses and establish any relationship(s) with LAI. Both intra- and inter-day variability of EBC H(2)O(2) concentration were large, while those of pH were small. No significant difference in the intra-day or inter-day H(2)O(2) concentrations or pH measurements were found in control or LAI horses, except for inter-day H(2)O(2) concentration in horses with LAI (p=0.019). There was no significant difference in EBC pH or H(2)O(2) concentration between control and LAI horses, however a trend for a reduced pH in horses with LAI was observed.

摘要

测量呼出气体冷凝液（EBC）中的过氧化氢（H₂O₂）浓度和pH值，对于检测和监测人类哮喘很有用。相比之下，关于这些参数用于研究马的下呼吸道炎症（LAI）的信息有限。本研究的目的是调查马EBC中H₂O₂浓度和pH值的日内和日间变化，并确定与LAI的任何关系。EBC中H₂O₂浓度的日内和日间变异性都很大，而pH值的变异性很小。在对照马或患LAI的马中，未发现日内或日间H₂O₂浓度或pH测量值有显著差异，但患LAI的马的日间H₂O₂浓度除外（p = 0.019）。对照马和患LAI的马之间的EBC pH值或H₂O₂浓度没有显著差异，然而观察到患LAI的马有pH值降低的趋势。