Skiepko Roman, Zietkowski Ziemowit, Tomasiak Maria Magdalena, Bodzenta-Lukaszyk Anna
Klinika Alergologii i Chorób Wewnetrznych, Akademii Medycznej w Białymstoku.
Przegl Lek. 2006;63(12):1321-5.
Exhaled breath condensate (EBC) is a novel, non-invasive method for obtaining samples from the lung. Use of exhaled condensate as a source of biomarkers is based on the hypothesis that aerosol particles of exhaled breath reflect the composition of airway lining fluid. The technique is simple to perform, effort-independent, rapid, may be repeated frequently, and can be easily perform even in young children, adults, or patients with severe disease. EBC contains large number of various mediators including isoprostanes, cysteinyl-leukotrienes, adenosine, hydrogen peroxide, peptides, cytokines. Concentrations of these biomarkers are influenced by inflammation, oxidative stress and modulated by therapeutic interventions. EBC can be used to assess airway inflammation and oxidative stress in the respiratory tract, in differential diagnosis of airway disease and in the treatment monitoring.
呼出气冷凝液（EBC）是一种从肺部获取样本的新型非侵入性方法。将呼出气冷凝液用作生物标志物来源的依据是这样一种假设，即呼出气中的气溶胶颗粒反映气道衬液的成分。该技术操作简单、无需费力、快速，可频繁重复，甚至在幼儿、成人或重症患者中也能轻松进行。EBC含有大量各种介质，包括异前列腺素、半胱氨酰白三烯、腺苷、过氧化氢、肽、细胞因子。这些生物标志物的浓度受炎症、氧化应激影响，并受治疗干预的调节。EBC可用于评估呼吸道中的气道炎症和氧化应激、气道疾病的鉴别诊断以及治疗监测。
