桦树皮提取物、桦木醇和桦木酸对人胃癌及胰腺癌药物敏感和耐药细胞系的细胞毒性作用比较。
Comparision of the cytotoxic effects of birch bark extract, betulin and betulinic acid towards human gastric carcinoma and pancreatic carcinoma drug-sensitive and drug-resistant cell lines.
作者信息
Drag Marcin, Surowiak Pawel, Drag-Zalesinska Malgorzata, Dietel Manfred, Lage Hermann, Oleksyszyn Józef
机构信息
Wroclaw University of Technology, Wybrzeze Wyspianskiego, Poland.
出版信息
Molecules. 2009 Apr 24;14(4):1639-51. doi: 10.3390/molecules14041639.
Abstract
Betulin and betulinic acid are naturally occurring pentacyclic triterpenes showing cytotoxicity towards a number of cancer cell lines. These compounds can be found in the bark of the many plants. In this report we have compared the cytotoxic activity of crude birch bark extract and purified betulin and betulinic acid towards human gastric carcinoma (EPG85-257) and human pancreatic carcinoma (EPP85-181) drug-sensitive and drug-resistant (daunorubicin and mitoxantrone) cell lines. Our results show significant differences in sensitivity between cell lines depending on the compound used, and suggest that both betulin and betulinic acid can be considered as a promising leads in the treatment of cancer.
摘要
桦木醇和桦木酸是天然存在的五环三萜，对多种癌细胞系具有细胞毒性。这些化合物存在于许多植物的树皮中。在本报告中，我们比较了桦树皮粗提物、纯化的桦木醇和桦木酸对人胃癌（EPG85 - 257）和人胰腺癌（EPP85 - 181）药物敏感及耐药（柔红霉素和米托蒽醌）细胞系的细胞毒性活性。我们的结果表明，根据所使用的化合物不同，细胞系之间的敏感性存在显著差异，并表明桦木醇和桦木酸都可被视为治疗癌症的有前景的先导化合物。
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