Takibayeva Altynaray T, Zhumabayeva Gulistan K, Bakibaev Abdigali A, Demets Olga V, Lyapunova Maria V, Mamaeva Elena A, Yerkassov Rakhmetulla Sh, Kassenov Rymchan Z, Ibrayev Marat K
Department of Chemistry and Chemical Technologies, NJSC Karaganda Technical University Named after Abylkas Saginov, Karaganda 100027, Kazakhstan.
Faculty of Natural Sciences, L.N. Gumilyov Eurasian National University, Astana 010000, Kazakhstan.
Molecules. 2023 Aug 8;28(16):5946. doi: 10.3390/molecules28165946.
This scientific work presents practical and theoretical material on the methods of analysis and identification of betulin and its key derivatives. The properties of betulin and its derivatives, which are determined by the structural features of this class of compounds and their tendency to form dimers, polymorphism and isomerization, are considered. This article outlines ways to improve not only the bioavailability but also the solubility of triterpenoids, as well as any hydrophobic drug substances, through chemical transformations by introducing various functional groups, such as carboxyl, hydroxyl, amino, phosphate/phosphonate and carbonyl. The authors of this article summarized the physicochemical characteristics of betulin and its compounds, systematized the literature data on IR and NMR spectroscopy and gave the melting temperatures of key acids and aldehydes based on betulin.
这项科学工作展示了关于桦木醇及其关键衍生物的分析和鉴定方法的实践和理论材料。考虑了桦木醇及其衍生物的性质，这些性质由这类化合物的结构特征以及它们形成二聚体、多晶型和异构化的倾向所决定。本文概述了通过引入各种官能团（如羧基、羟基、氨基、磷酸/膦酸酯和羰基）进行化学转化来提高三萜类化合物以及任何疏水药物物质的生物利用度和溶解度的方法。本文作者总结了桦木醇及其化合物的物理化学特性，对红外光谱和核磁共振光谱的文献数据进行了系统化整理，并给出了基于桦木醇的关键酸和醛的熔点。
