肠道微生物群调节肼的毒性：一项代谢组学研究。
Gut microbiome modulates the toxicity of hydrazine: a metabonomic study.
作者信息
Swann Jonathan, Wang Yulan, Abecia Leticia, Costabile Adele, Tuohy Kieran, Gibson Glenn, Roberts David, Sidaway James, Jones Huw, Wilson Ian D, Nicholson Jeremy, Holmes Elaine
机构信息
Department of Biomolecular Medicine, Division of Surgery, Oncology, Reproductive Biology and Anaesthetics (SORA), Faculty of Medicine, Imperial College London, South Kensington Campus, London SW72AZ, UK.
出版信息
Mol Biosyst. 2009 Apr;5(4):351-5. doi: 10.1039/b811468d. Epub 2009 Jan 23.
The influence of gut microbiota on the toxicity and metabolism of hydrazine has been investigated in germ-free and 'conventional' Sprague Dawley rats using 1H NMR based metabonomic analysis of urine and plasma. Toxicity was more severe in germ-free rats compared with conventional rats for equivalent exposures indicating that bacterial presence altered the nature or extent of response to hydrazine and that the toxic response can vary markedly in the absence of a functional microbiome.
利用基于氢核磁共振（1H NMR）的尿液和血浆代谢组学分析，在无菌和“常规”斯普拉格-道利大鼠中研究了肠道微生物群对肼的毒性和代谢的影响。在同等暴露条件下，无菌大鼠的毒性比常规大鼠更严重，这表明细菌的存在改变了对肼的反应性质或程度，并且在缺乏功能性微生物群的情况下，毒性反应可能会有显著差异。
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