Hossain Zakir, Hirata Takashi
Division of Applied Biosciences, Graduate School of Agriculture, Kyoto University, Kyoto 606-8502, Japan.
Mol Biosyst. 2008 Dec;4(12):1181-5. doi: 10.1039/b800402a. Epub 2008 Oct 2.
The intestinal barrier plays a critical role in humans in the transport of nutrients and macromolecules. At the same time, it has to provide an effective barrier to harmful macromolecules and microorganisms. The tight junction (TJ) is an essential component of this barrier. The junctional complexes of the plasma membrane are not simply epithelial barriers in paracellular transport or barriers preventing diffusion in the plasma membrane, but also contain proteins involved in signal transduction and the maintenance of the physiological epithelial cell state. Occludin, claudin, junctional adhesion molecules, and the coxsackie virus and adenovirus receptor are the major components of TJs. This article highlights the structure and function of TJs as well as the molecular interactions occurring during permeation through TJs.
肠道屏障在人体营养物质和大分子的运输中起着关键作用。与此同时，它必须对有害大分子和微生物提供有效的屏障。紧密连接（TJ）是这一屏障的重要组成部分。质膜的连接复合体不仅是细胞旁运输中的上皮屏障或防止质膜扩散的屏障，还包含参与信号转导和维持生理上皮细胞状态的蛋白质。闭合蛋白、紧密连接蛋白、连接黏附分子以及柯萨奇病毒和腺病毒受体是紧密连接的主要组成部分。本文重点介绍了紧密连接的结构和功能，以及通过紧密连接渗透过程中发生的分子相互作用。
