Hakenbeck Regine, Madhour Abderrahim, Denapaite Dalia, Brückner Reinhold
Department of Microbiology, University of Kaiserslautern, Germany.
FEMS Microbiol Rev. 2009 May;33(3):572-86. doi: 10.1111/j.1574-6976.2009.00172.x.
The pneumococcal choline-containing teichoic acids are targeted by cholinebinding proteins (CBPs), major surface components implicated in the interaction with host cells and bacterial cell physiology. CBPs also occur in closely related commensal species, Streptococcus oralis and Streptococcus mitis, and many strains of these species contain choline in their cell wall. Physiologically relevant CBPs including cell wall lytic enzymes are highly conserved between Streptococcus pneumoniae and S. mitis. In contrast, the virulence-associated CBPs, CbpA, PspA and PcpA, are S. pneumoniae specific and are thus relevant for the characteristic properties of this species.
肺炎球菌含胆碱的磷壁酸是胆碱结合蛋白（CBPs）的作用靶点，胆碱结合蛋白是与宿主细胞相互作用及细菌细胞生理学相关的主要表面成分。胆碱结合蛋白也存在于密切相关的共生菌口腔链球菌和缓症链球菌中，这些菌种的许多菌株在其细胞壁中含有胆碱。包括细胞壁裂解酶在内的生理相关胆碱结合蛋白在肺炎链球菌和缓症链球菌之间高度保守。相比之下，与毒力相关的胆碱结合蛋白CbpA、PspA和PcpA是肺炎链球菌特有的，因此与该菌种的特性相关。
