Colomba Claudia, Garbo Valeria, Boncori Giovanni, Albano Chiara, Bagarello Sara, Condemi Anna, Giordano Salvatore, Canduscio Laura A, Gallo Cristina, Parrinello Gaspare, Cascio Antonio
Department of Health Promotion, Maternal and Infant Care, Internal Medicine and Medical Specialties, University of Palermo, 90100 Palermo, Italy.
Division of Pediatric Infectious Diseases, "G. Di Cristina" Hospital, ARNAS Civico Di Cristina Benfratelli, 90100 Palermo, Italy.
Antibiotics (Basel). 2023 Jul 23;12(7):1222. doi: 10.3390/antibiotics12071222.
, a normal inhabitant of the oral cavity, is a member of Viridans Group Streptococci (VGS). Generally recognized as a causative agent of invasive diseases in immunocompromised patients, is considered to have low pathogenic potential in immunocompetent individuals. We present a rare case of sinusitis complicated by meningitis and cerebral sino-venous thrombosis (CSVT) caused by in a previously healthy 12-year-old boy with poor oral health status. With the aim of understanding the real pathogenic role of this microorganism, an extensive review of the literature about invasive diseases due to in pediatric patients was performed. Our data define the critical role of this microorganism in invasive infections, especially in immunocompetent children and in the presence of apparently harmful conditions such as sinusitis and caries. Attention should be paid to the choice of therapy because of VGS's emerging antimicrobial resistance patterns.
作为口腔的正常寄居菌，是草绿色链球菌群（VGS）的一员。通常被认为是免疫功能低下患者侵袭性疾病的病原体，在免疫功能正常的个体中被认为致病潜力较低。我们报告了一例罕见病例，一名口腔健康状况较差的12岁既往健康男孩，因 并发鼻窦炎、脑膜炎和脑静脉窦血栓形成（CSVT）。为了了解这种微生物的真正致病作用，我们对有关儿科患者因 引起的侵袭性疾病的文献进行了广泛综述。我们的数据确定了这种微生物在侵袭性感染中的关键作用，尤其是在免疫功能正常的儿童以及存在鼻窦炎和龋齿等明显有害状况时。由于VGS出现的抗菌药物耐药模式，应注意治疗方案的选择。
