• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
A novel codon insert in protease of clade B HIV type 1.1型B亚型HIV蛋白酶中一种新的密码子插入。
AIDS Res Hum Retroviruses. 2009 May;25(5):547-50. doi: 10.1089/aid.2008.0310.
2
Novel codon insert in HIV type 1 clade B reverse transcriptase associated with low-level viremia during antiretroviral therapy.1型人类免疫缺陷病毒B亚型逆转录酶中的新型密码子插入与抗逆转录病毒治疗期间的低水平病毒血症相关。
AIDS Res Hum Retroviruses. 2014 Feb;30(2):165-9. doi: 10.1089/AID.2013.0202. Epub 2013 Oct 5.
3
Low prevalence of primary antiretroviral resistance mutations and predominance of HIV-1 clade C at polymerase gene in newly diagnosed individuals from south Brazil.巴西南部新诊断个体中，原发性抗逆转录病毒耐药性突变的低流行率及聚合酶基因处HIV-1 C亚型的优势地位。
Virus Res. 2006 Mar;116(1-2):201-7. doi: 10.1016/j.virusres.2005.10.004. Epub 2005 Dec 5.
4
New two-amino acid insertion near codon 70 of the HIV type 1 protease gene.
AIDS Res Hum Retroviruses. 2005 Apr;21(4):311-3. doi: 10.1089/aid.2005.21.311.
5
Mutation patterns of the reverse transcriptase and protease genes in human immunodeficiency virus type 1-infected patients undergoing combination therapy: survey of 787 sequences.接受联合治疗的1型人类免疫缺陷病毒感染患者逆转录酶和蛋白酶基因的突变模式：787个序列的调查
J Clin Microbiol. 1999 Dec;37(12):4099-106. doi: 10.1128/JCM.37.12.4099-4106.1999.
6
First observation of HIV type 1 drug resistance mutations in Algeria.阿尔及利亚首次观察到1型人类免疫缺陷病毒耐药性突变。
AIDS Res Hum Retroviruses. 2008 Nov;24(11):1467-73. doi: 10.1089/aid.2008.0087.
7
Detection of genotypically drug-resistant HIV-1 variants and non-B subtypes in recently infected antiretroviral-naive adults in Italy.在意大利近期感染且未接受过抗逆转录病毒治疗的成年患者中检测基因耐药性HIV-1变异体和非B亚型
AIDS. 2000 Sep 29;14(14):2204-6. doi: 10.1097/00002030-200009290-00019.
8
Increasing prevalence of non-clade B HIV-1 strains in heterosexual men and women, as monitored by analysis of reverse transcriptase and protease sequences.通过对逆转录酶和蛋白酶序列的分析监测发现，异性恋男性和女性中非B亚型HIV-1毒株的流行率不断上升。
J Acquir Immune Defic Syndr. 2001 Aug 15;27(5):499-505. doi: 10.1097/00126334-200108150-00012.
9
HIV type 1 genotypic variation in an antiretroviral treatment-naive population in southern India.印度南部初治抗逆转录病毒治疗人群中的1型人类免疫缺陷病毒基因变异
AIDS Res Hum Retroviruses. 2005 Apr;21(4):301-5. doi: 10.1089/aid.2005.21.301.
10
Natural residues versus antiretroviral drug-selected mutations in HIV type 1 group O reverse transcriptase and protease related to virological drug failure in vivo.1型人类免疫缺陷病毒O组逆转录酶和蛋白酶中与体内病毒学治疗失败相关的天然残基与抗逆转录病毒药物选择的突变
AIDS Res Hum Retroviruses. 2000 Sep 20;16(14):1385-94. doi: 10.1089/08892220050140937.

引用本文的文献

1
Novel codon insert in HIV type 1 clade B reverse transcriptase associated with low-level viremia during antiretroviral therapy.1型人类免疫缺陷病毒B亚型逆转录酶中的新型密码子插入与抗逆转录病毒治疗期间的低水平病毒血症相关。
AIDS Res Hum Retroviruses. 2014 Feb;30(2):165-9. doi: 10.1089/AID.2013.0202. Epub 2013 Oct 5.

本文引用的文献

1
Antiretroviral treatment of adult HIV infection: 2008 recommendations of the International AIDS Society-USA panel.成人HIV感染的抗逆转录病毒治疗：美国国际艾滋病协会专家组2008年建议
JAMA. 2008 Aug 6;300(5):555-70. doi: 10.1001/jama.300.5.555.
2
Antiretroviral drug resistance testing in adult HIV-1 infection: 2008 recommendations of an International AIDS Society-USA panel.成人HIV-1感染的抗逆转录病毒药物耐药性检测：美国国际艾滋病协会专家组2008年建议
Clin Infect Dis. 2008 Jul 15;47(2):266-85. doi: 10.1086/589297.
3
Ninety-nine is not enough: molecular characterization of inhibitor-resistant human immunodeficiency virus type 1 protease mutants with insertions in the flap region.99个还不够：对在翼片区域有插入的耐抑制剂的1型人类免疫缺陷病毒蛋白酶突变体的分子特征分析
J Virol. 2008 Jun;82(12):5869-78. doi: 10.1128/JVI.02325-07. Epub 2008 Apr 9.
4
Insertions in the human immunodeficiency virus type 1 protease and reverse transcriptase genes: clinical impact and molecular mechanisms.人类免疫缺陷病毒1型蛋白酶和逆转录酶基因中的插入：临床影响和分子机制
Antimicrob Agents Chemother. 2005 Jul;49(7):2575-82. doi: 10.1128/AAC.49.7.2575-2582.2005.
5
Functional correlates of insertion mutations in the protease gene of human immunodeficiency virus type 1 isolates from patients.来自患者的1型人类免疫缺陷病毒分离株蛋白酶基因插入突变的功能相关性
J Virol. 2001 Nov;75(22):11227-33. doi: 10.1128/JVI.75.22.11227-11233.2001.
6
HIV chemotherapy.艾滋病化疗。
Nature. 2001 Apr 19;410(6831):995-1001. doi: 10.1038/35073673.
7
A 6-basepair insert in the reverse transcriptase gene of human immunodeficiency virus type 1 confers resistance to multiple nucleoside inhibitors.人类免疫缺陷病毒1型逆转录酶基因中的一个6碱基对插入赋予对多种核苷类抑制剂的抗性。
J Clin Invest. 1998 Nov 15;102(10):1769-75. doi: 10.1172/JCI4948.
8
Pausing of reverse transcriptase on retroviral RNA templates is influenced by secondary structures both 5' and 3' of the catalytic site.逆转录酶在逆转录病毒RNA模板上的暂停受到催化位点5'端和3'端二级结构的影响。
Nucleic Acids Res. 1998 Jul 15;26(14):3433-42. doi: 10.1093/nar/26.14.3433.
9
HIV with reduced sensitivity to zidovudine (AZT) isolated during prolonged therapy.在长期治疗期间分离出的对齐多夫定（AZT）敏感性降低的HIV。
Science. 1989 Mar 31;243(4899):1731-4. doi: 10.1126/science.2467383.

1型B亚型HIV蛋白酶中一种新的密码子插入。

A novel codon insert in protease of clade B HIV type 1.

作者信息

Jordan Parris S, Poon Art, Eron Joseph, Squires Kathleen, Ignacio Caroline, Richman Douglas D, Smith Davey M

机构信息

University of California, San Diego, La Jolla, California 92093, USA.

出版信息

AIDS Res Hum Retroviruses. 2009 May;25(5):547-50. doi: 10.1089/aid.2008.0310.

DOI:10.1089/aid.2008.0310
PMID:19397401
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2749665/
Abstract

A novel combination of three codon inserts in the pol coding region of HIV-1 RNA was identified in a highly antiretroviral experienced study subject with HIV-1 infection. A one codon insert was observed in the protease region between codon 40 and 41 simultaneously with a two codon insert present in the reverse transcriptase region at codon 69.

摘要

在一名有丰富抗逆转录病毒治疗经验的HIV-1感染研究对象中，发现了HIV-1 RNA的pol编码区中三种密码子插入的新组合。在蛋白酶区域的第40和41密码子之间观察到一个密码子插入，同时在逆转录酶区域的第69密码子处存在一个两个密码子的插入。