Chern Peggy L, Baum Christian L, Arpey Christopher J
Division of Dermatology and Cutaneous Surgery, Scripps Clinic, La Jolla, Caifornia 92037, USA.
Dermatol Surg. 2009 Jun;35(6):891-906. doi: 10.1111/j.1524-4725.2009.01153.x. Epub 2009 Apr 6.
Various biologic dressings have been developed in an effort to find the ideal skin substitute for use in acute and chronic wounds. There are many potential uses for such dressings, but no panaceas exist. Because millions of health care dollars are spent each year on wound care, and a great deal of patient morbidity occurs from these wounds, the search for new and better dressings is likely to continue.
To review the current evidence regarding the utility, outcomes, and adverse effects of the available biologic dressings, with a particular focus on use in acute surgical wounds and applicability to dermatologic surgery.
PubMed literature search and review of data on biologic dressings with particular attention to the past 2 decades. Emphasis was placed on peer-reviewed manuscripts and larger series.
There is extensive literature regarding the use of biologic dressings in chronic wounds, such as venous leg ulcers and burns, but studies evaluating these dressings in acute surgical wounds and dermatologic surgery have been limited. There appear to be specific surgical settings in which such dressings may be of particular use, in addition to limitations of their use. Additional studies, particularly randomized and comparative trials, would be highly desirable.
为了找到用于急慢性伤口的理想皮肤替代物，人们研发了多种生物敷料。这类敷料有许多潜在用途，但不存在万灵药。由于每年有数百万美元用于伤口护理，且这些伤口导致大量患者发病，因此寻找新的更好的敷料的工作可能会继续。
回顾现有生物敷料的效用、疗效及不良反应的当前证据，特别关注其在急性手术伤口中的应用以及在皮肤科手术中的适用性。
通过PubMed文献检索并回顾生物敷料的数据，特别关注过去20年的情况。重点是经过同行评审的手稿和较大规模的系列研究。
关于生物敷料在慢性伤口（如下肢静脉溃疡和烧伤）中的应用有大量文献，但评估这些敷料在急性手术伤口和皮肤科手术中的研究有限。除了其使用的局限性外，似乎在某些特定的手术环境中这类敷料可能特别有用。非常需要进行更多研究，尤其是随机对照试验和比较试验。
