Department of Metabolic Disorders, Merck Research Laboratories, Rahway, NJ 07065, USA.
Peptides. 2009 Nov;30(11):2008-13. doi: 10.1016/j.peptides.2009.04.009. Epub 2009 May 4.
Melanin-concentrating hormone (MCH) is an important neuropeptide hormone involved in multiple physiological processes. Peptide derivatives of MCH have been developed as tools to aid research including potent radioligands, receptor selective agonists, and potent antagonists. These tools have been used to further understand the role of MCH in physiology, primarily in rodents. However, the tools could also help elucidate the role for MCHR1 and MCHR2 in mediating MCH signaling in higher species.
黑皮质素浓缩激素（MCH）是一种重要的神经肽激素，参与多种生理过程。MCH 的肽衍生物已被开发为研究工具，包括强效放射性配体、受体选择性激动剂和强效拮抗剂。这些工具已被用于进一步了解 MCH 在生理学中的作用，主要在啮齿动物中。然而，这些工具也有助于阐明 MCHR1 和 MCHR2 在调节高等物种中 MCH 信号转导中的作用。
