Cardoso Vilela Fabiana, Soncini Roseli, Giusti-Paiva Alexandre
Department of Biomedical Science, Federal University of Alfenas, Alfenas-MG, Brazil.
J Ethnopharmacol. 2009 Jul 15;124(2):325-7. doi: 10.1016/j.jep.2009.04.029. Epub 2009 May 3.
Sonchus oleraceus L. has been used as a general tonic in Brazilian folk medicine. Nevertheless, available scientific information regarding this species is scarce; there are no reports related to its possible effect on the central nervous system.
This study was conducted to establish the anxiolytic effect of extracts from the aerial parts of Sonchus oleraceus.
This study evaluated the effect of hydroethanolic and dichloromethane extracts of Sonchus oleraceus in mice submitted to the elevated plus-maze and open-field tests. Clonazepam was used as the standard drug.
In the elevated plus-maze test, the Sonchus oleraceus extracts increased the percentage of open arm entries (P<0.05) and time spent in the open-arm portions of the maze (P<0.05). The extracts induce an anti-thigmotactic effect, evidenced by increased locomotor activity into the central part of the open field set-up (P<0.05). The extracts administered at 30-300 mg/kg, p.o. had a similar anxiolytic effect to clonazepam (0.5 mg/kg, p.o.).
These data indicate that Sonchus oleraceus extract exerts an anxiolytic-like effect on mice.
苣荬菜在巴西民间医学中被用作滋补剂。然而，关于该物种的现有科学信息匮乏；尚无关于其对中枢神经系统可能作用的报道。
本研究旨在确定苣荬菜地上部分提取物的抗焦虑作用。
本研究评估了苣荬菜的水乙醇提取物和二氯甲烷提取物对接受高架十字迷宫试验和旷场试验的小鼠的影响。氯硝西泮用作标准药物。
在高架十字迷宫试验中，苣荬菜提取物增加了进入开放臂的百分比（P<0.05）以及在迷宫开放臂部分停留的时间（P<0.05）。提取物诱导了抗趋触性效应，表现为在旷场中央区域的运动活动增加（P<0.05）。以30 - 300 mg/kg口服给药的提取物具有与氯硝西泮（0.5 mg/kg，口服）相似的抗焦虑作用。
这些数据表明苣荬菜提取物对小鼠具有类似抗焦虑的作用。
