Vilela Fabiana Cardoso, de Mesquita Padilha Marina, Dos Santos-E-Silva Lucas, Alves-da-Silva Geraldo, Giusti-Paiva Alexandre
Department of Biomedical Science, Federal University of Alfenas-MG, 37130-000 Alfenas, Brazil.
J Ethnopharmacol. 2009 Jul 15;124(2):306-10. doi: 10.1016/j.jep.2009.04.037. Epub 2009 May 3.
Sonchus oleraceus L. has been used to relieve pain in Brazilian folk medicine.
Sonchus oleraceus L. has been used to relieve pain in Brazilian folk medicine. This study was conducted to establish the antinociceptive properties of hydroethanolic and dichloromethane extracts from aerial parts of Sonchus oleraceus in mice using chemical and thermal models of nociception.
The formalin, hot plate, and tail immersion tests as well as acetic acid-induced writhing were used to investigate the antinociceptive activity in mice.
Given orally, the extracts at test doses of 30-300 mg/kg, produced significant inhibitions on chemical nociception induced by intraperitoneal acetic acid and subplantar formalin since decreased the number of writhing episodes and the time licking. Treatment with the extracts in the same doses produced a significant increase of the reaction time in tail immersion and in the hot plate test. The extracts administered at 300 mg/kg, p.o. had a stronger antinociceptive effect than indomethacin (5mg/kg, p.o.) and morphine (10mg/kg, p.o.).
The extracts of Sonchus oleraceus markedly demonstrated antinociceptive action in mice, which supports previous claims of its traditional use.
在巴西民间医学中，苣荬菜已被用于缓解疼痛。
在巴西民间医学中，苣荬菜已被用于缓解疼痛。本研究旨在利用化学和热痛觉模型，确定苣荬菜地上部分的水乙醇提取物和二氯甲烷提取物在小鼠中的抗伤害感受特性。
采用福尔马林试验、热板试验、尾浸试验以及醋酸诱导扭体试验来研究小鼠的抗伤害感受活性。
口服给药时，30 - 300 mg/kg测试剂量的提取物对腹腔注射醋酸和足底注射福尔马林诱导的化学性伤害感受产生了显著抑制作用，减少了扭体发作次数和舔舐时间。相同剂量的提取物处理使尾浸试验和热板试验中的反应时间显著延长。300 mg/kg口服给药的提取物比吲哚美辛（5mg/kg，口服）和吗啡（10mg/kg，口服）具有更强的抗伤害感受作用。
苣荬菜提取物在小鼠中显著表现出抗伤害感受作用，这支持了其传统用途的先前说法。
