• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

孕期接触低剂量邻苯二甲酸二丁酯的成年大鼠表现出梳理行为减少。

Adult rats exposed to low-doses of di-n-butyl phthalate during gestation exhibit decreased grooming behavior.

作者信息

Hoshi Hideo, Ohtsuka Teruya

机构信息

Department of Ophthalmology and Visual Science, University of Texas at Houston, Houston, TX 77030, USA.

出版信息

Bull Environ Contam Toxicol. 2009 Jul;83(1):62-6. doi: 10.1007/s00128-009-9729-1. Epub 2009 Apr 28.

DOI:10.1007/s00128-009-9729-1
PMID:19399352
Abstract

Developmental neurotoxicity of low-dose di-n-butyl phthalate (DBP) to rats was studied. Pregnant rats were orally given DBP at doses less than 1.0 mg/kg/day during gestation period. The body weight of all dams and their offspring as well as the offspring's motor function showed no significant adverse effect. At 21 weeks, behaviors of male rats were examined by placing into a test cage. The rats born from dams exposed to 10 microg DBP/kg/day exhibited a significant decrease of grooming. This indicates low-dose DBP adversely affects emotional stability in a novel environment.

摘要

研究了低剂量邻苯二甲酸二正丁酯（DBP）对大鼠的发育神经毒性。在妊娠期，给怀孕大鼠口服低于1.0毫克/千克/天剂量的DBP。所有母鼠及其后代的体重以及后代的运动功能均未显示出明显的不良影响。在21周时，将雄性大鼠放入测试笼中检查其行为。出生于暴露于10微克DBP/千克/天剂量母鼠的大鼠出现明显的理毛行为减少。这表明低剂量DBP会对新环境中的情绪稳定性产生不利影响。

相似文献

1
Adult rats exposed to low-doses of di-n-butyl phthalate during gestation exhibit decreased grooming behavior.孕期接触低剂量邻苯二甲酸二丁酯的成年大鼠表现出梳理行为减少。
Bull Environ Contam Toxicol. 2009 Jul;83(1):62-6. doi: 10.1007/s00128-009-9729-1. Epub 2009 Apr 28.
2
Reproductive and developmental toxicity in F1 Sprague-Dawley male rats exposed to di-n-butyl phthalate in utero and during lactation and determination of its NOAEL.子宫内和哺乳期暴露于邻苯二甲酸二正丁酯的F1代斯普拉格-道利雄性大鼠的生殖和发育毒性及其无观察到有害作用水平的确定
Reprod Toxicol. 2004 Jul;18(5):669-76. doi: 10.1016/j.reprotox.2004.04.009.
3
Reproductive toxicity and pharmacokinetics of di-n-butyl phthalate (DBP) following dietary exposure of pregnant rats.孕期大鼠经口摄入邻苯二甲酸二丁酯（DBP）后的生殖毒性及药代动力学
Birth Defects Res B Dev Reprod Toxicol. 2009 Aug;86(4):345-54. doi: 10.1002/bdrb.20199.
4
Study on developmental abnormalities in hypospadiac male rats induced by maternal exposure to di-n-butyl phthalate (DBP).母体暴露于邻苯二甲酸二丁酯（DBP）诱导雄性尿道下裂大鼠发育异常的研究。
Toxicology. 2007 Apr 11;232(3):286-93. doi: 10.1016/j.tox.2007.01.018. Epub 2007 Feb 3.
5
Diverse developmental toxicity of di-n-butyl phthalate in both sexes of rat offspring after maternal exposure during the period from late gestation through lactation.在从妊娠晚期到哺乳期的母鼠暴露期间，邻苯二甲酸二丁酯对大鼠后代雌雄两性具有多种发育毒性。
Toxicology. 2004 Oct 15;203(1-3):221-38. doi: 10.1016/j.tox.2004.06.013.
6
Neurobehavioral toxicity study of dibutyl phthalate on rats following in utero and lactational exposure.孕期和哺乳期经口暴露二丁基邻苯二甲酸酯对大鼠神经行为毒性的研究。
J Appl Toxicol. 2009 Oct;29(7):603-11. doi: 10.1002/jat.1447.
7
Molecular and toxicologic research in newborn hypospadiac male rats following in utero exposure to di-n-butyl phthalate (DBP).子宫内暴露于邻苯二甲酸二正丁酯（DBP）的新生尿道下裂雄性大鼠的分子和毒理学研究
Toxicology. 2009 Jun 16;260(1-3):120-5. doi: 10.1016/j.tox.2009.03.017. Epub 2009 Apr 5.
8
Critical window of male reproductive tract development in rats following gestational exposure to di-n-butyl phthalate.孕期暴露于邻苯二甲酸二丁酯后大鼠雄性生殖道发育的关键窗口期。
Birth Defects Res B Dev Reprod Toxicol. 2005 Jun;74(3):277-85. doi: 10.1002/bdrb.20050.
9
Assessment of the developmental toxicity, metabolism, and placental transfer of Di-n-butyl phthalate administered to pregnant rats.对给予怀孕大鼠的邻苯二甲酸二正丁酯的发育毒性、代谢及胎盘转运的评估。
Toxicol Sci. 1998 Oct;45(2):212-24. doi: 10.1006/toxs.1998.2518.
10
Exposure to di(n-butyl)phthalate and benzo(a)pyrene alters IL-1β secretion and subset expression of testicular macrophages, resulting in decreased testosterone production in rats.二丁基邻苯二甲酸酯和苯并(a)芘暴露会改变睾丸巨噬细胞的白细胞介素-1β分泌和亚群表达，导致大鼠睾丸酮生成减少。
Toxicol Appl Pharmacol. 2010 Oct 1;248(1):28-37. doi: 10.1016/j.taap.2010.07.008. Epub 2010 Jul 23.

引用本文的文献

1
Embryotoxicity and teratogenesis of orthodontic acrylic resin in zebrafish.正畸丙烯酸树脂对斑马鱼的胚胎毒性和致畸作用。
Heliyon. 2024 Jun 7;10(12):e32067. doi: 10.1016/j.heliyon.2024.e32067. eCollection 2024 Jun 30.
2
A Mixture of Urinary Phthalate Metabolite Concentrations During Pregnancy and Offspring Social Responsiveness Scale Scores.孕期尿液邻苯二甲酸酯代谢物浓度混合与儿童社交反应量表评分。
Epidemiology. 2024 Jan 1;35(1):84-93. doi: 10.1097/EDE.0000000000001682. Epub 2023 Oct 11.
3
Prenatal Exposure to Nonpersistent Chemical Mixtures and Offspring IQ and Emotional and Behavioral Problems.
产前暴露于非持久性化学混合物与后代的智商以及情绪和行为问题。
Environ Sci Technol. 2021 Dec 21;55(24):16502-16514. doi: 10.1021/acs.est.1c04455. Epub 2021 Dec 8.
4
Autistic-like traits in laboratory rodents exposed to phthalic acid esters during early development - an animal model of autism?早期发育阶段接触邻苯二甲酸酯的实验鼠出现类自闭症特征 - 自闭症动物模型？
Physiol Res. 2021 Jul 12;70(3):345-361. doi: 10.33549/physiolres.934570. Epub 2021 May 12.
5
Prenatal exposure to a wide range of environmental chemicals and child behaviour between 3 and 7 years of age - An exposome-based approach in 5 European cohorts.孕期暴露于多种环境化学物质与 3 至 7 岁儿童行为之间的关系——5 个欧洲队列的基于暴露组学的研究方法
Sci Total Environ. 2021 Apr 1;763:144115. doi: 10.1016/j.scitotenv.2020.144115. Epub 2020 Dec 15.
6
A Review of Biomonitoring of Phthalate Exposures.邻苯二甲酸酯暴露生物监测综述
Toxics. 2019 Apr 5;7(2):21. doi: 10.3390/toxics7020021.
7
Effects of Perinatal Exposure to Phthalates and a High-Fat Diet on Maternal Behavior and Pup Development and Social Play.围产期暴露于邻苯二甲酸盐和高脂饮食对母性行为、幼崽发育及社交行为的影响。
Endocrinology. 2018 Feb 1;159(2):1088-1105. doi: 10.1210/en.2017-03047.
8
Prenatal Exposure to Nonpersistent Endocrine Disruptors and Behavior in Boys at 3 and 5 Years.产前暴露于非持久性内分泌干扰物与3岁和5岁男孩的行为
Environ Health Perspect. 2017 Sep 15;125(9):097014. doi: 10.1289/EHP1314.
9
Paternal and maternal preconception urinary phthalate metabolite concentrations and child behavior.父母孕前尿中邻苯二甲酸酯代谢物浓度与儿童行为
Environ Res. 2017 Oct;158:720-728. doi: 10.1016/j.envres.2017.07.032. Epub 2017 Jul 21.
10
Phthalates induce neurotoxicity affecting locomotor and thermotactic behaviors and AFD neurons through oxidative stress in Caenorhabditis elegans.邻苯二甲酸酯通过氧化应激诱导秀丽隐杆线虫的运动和趋温行为以及 AFD 神经元的神经毒性。
PLoS One. 2013 Dec 12;8(12):e82657. doi: 10.1371/journal.pone.0082657. eCollection 2013.