Department of Child and Adolescent Psychiatry, Erasmus MC University Medical Center Rotterdam, Rotterdam, 3015 CN The Netherlands.
The Generation R Study Group, Erasmus MC University Medical Center Rotterdam, The Generation R Study Group, Rotterdam, 3015 CN The Netherlands.
Environ Sci Technol. 2021 Dec 21;55(24):16502-16514. doi: 10.1021/acs.est.1c04455. Epub 2021 Dec 8.
Prenatal exposure to nonpersistent chemicals such as phthalates, bisphenols, and organophosphate (OP) pesticides is ubiquitous and occurs in mixtures. So far, epidemiological studies investigating neurodevelopmental consequences of these exposures have mainly been restricted to single-pollutant models. Thus, we studied the association between prenatal exposure to nonpersistent chemical mixtures and child IQ and emotional and behavioral problems. Data came from 782 mother-child pairs. Eleven phthalate, one bisphenol, and five OP pesticide urinary exposure biomarkers were measured three times during pregnancy and averaged. Nonverbal IQ, internalizing and attention problems, aggressive behavior, and autistic traits were assessed at child age 6 years. We used quantile g-computation to estimate the change in each outcome per quartile increase in all chemicals within the mixture. Higher exposure to the mixture was associated with lower nonverbal IQ (-4.0 points (95%CI = -7.0, -1.0), -5.5 points (95%CI = -10.2, -0.9), and -4.6 points (95%CI = -10.8, 1.5) for the second, third, and fourth quartile, respectively, compared to the first quartile). These results were mainly driven by the phthalate mixture. No association was observed with emotional and behavioral problems. Prenatal exposure to nonpersistent chemical mixtures was associated with lower nonverbal IQ in children. Exposure to chemical mixtures during gestation is universal and may impact neurodevelopment.
产前暴露于邻苯二甲酸酯、双酚和有机磷（OP）农药等非持久性化学物质是普遍存在的，并且以混合物的形式存在。到目前为止，研究这些暴露对神经发育影响的流行病学研究主要限于单一污染物模型。因此，我们研究了产前接触非持久性化学混合物与儿童智商以及情绪和行为问题之间的关系。数据来自 782 对母婴。在怀孕期间，我们测量了 11 种邻苯二甲酸酯、1 种双酚和 5 种 OP 农药的尿液暴露生物标志物，然后将其平均三次。在儿童 6 岁时，我们评估了非语言智商、内化和注意力问题、攻击性行为和自闭症特征。我们使用分位数 g 计算来估计每个混合物中所有化学物质每增加一个四分位数时每个结果的变化。与第一四分位数相比，混合物中更高的暴露水平与非语言智商降低有关（第二四分位数时降低 4.0 分（95%CI = -7.0，-1.0），第三四分位数时降低 5.5 分（95%CI = -10.2，-0.9），第四四分位数时降低 4.6 分（95%CI = -10.8，1.5））。这些结果主要是由邻苯二甲酸酯混合物驱动的。与情绪和行为问题没有关联。产前接触非持久性化学混合物与儿童非语言智商较低有关。怀孕期间接触化学混合物是普遍存在的，可能会影响神经发育。
