Farzin Faraz, Rivera Susan M, Hessl David
Department of Psychology, University of California, Davis, Davis, CA, USA.
J Autism Dev Disord. 2009 Jun;39(6):946-52. doi: 10.1007/s10803-009-0744-1. Epub 2009 Apr 28.
Gaze avoidance is a hallmark behavioral feature of fragile X syndrome (FXS), but little is known about whether abnormalities in the visual processing of faces, including disrupted autonomic reactivity, may underlie this behavior. Eye tracking was used to record fixations and pupil diameter while adolescents and young adults with FXS and sex- and age-matched typically developing controls passively viewed photographs of faces containing either a calm, happy, or fearful expression, preceded by a scrambled face matched on luminance. Results provide quantitative evidence for significant differences in gaze patterns and increased pupillary reactivity when individuals with FXS passively view static faces. Such abnormalities have significant implications in terms of understanding causes of gaze avoidance observed in individuals with FXS.
目光回避是脆性X综合征（FXS）的一个标志性行为特征，但对于面部视觉处理异常（包括自主反应紊乱）是否可能是这种行为的基础，人们知之甚少。在患有FXS的青少年和青年以及性别和年龄匹配的典型发育对照组被动观看包含平静、快乐或恐惧表情的面部照片（之前有一张在亮度上匹配的乱序面部照片）时，使用眼动追踪来记录注视点和瞳孔直径。结果提供了定量证据，表明患有FXS的个体在被动观看静态面部时，注视模式存在显著差异，瞳孔反应性增加。这些异常对于理解FXS个体中观察到的目光回避原因具有重要意义。
