Department of Hematology, Second Affiliated Hospital to Second Military Medical University, 415 Fengyang Rd, Shanghai 200003, PR China.
J Hematol Oncol. 2009 Apr 28;2:19. doi: 10.1186/1756-8722-2-19.
Multicentric Castleman's disease (MCD) is a rare lymphoproliferative disorder of unknown etiology and characterized by various clinical manifestations and multiple organ involvement. It has been reported in association with POEMS syndrome and can progress to Kaposi's sarcoma or malignant lymphoma. The disease runs a more aggressive course and a poor prognosis. Optimal therapies have not been well established up to now. We here reported a case of rare MCD complicated with multiple myeloma who received bortezomib and achieved very good remission. To our knowledge, this is the first report on MCD in the setting of multiple myeloma with good response to bortezomib.
多中心 Castleman 病（MCD）是一种罕见的淋巴组织增生性疾病，病因不明，其特征为多种临床表现和多器官受累。它与 POEMS 综合征相关，并可进展为卡波西肉瘤或恶性淋巴瘤。该疾病具有更具侵袭性的病程和较差的预后。到目前为止，尚未确立最佳的治疗方法。我们在此报告一例罕见的 MCD 合并多发性骨髓瘤患者，接受硼替佐米治疗后获得了非常好的缓解。据我们所知，这是首例报道多发性骨髓瘤患者对硼替佐米反应良好的 MCD 病例。
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