Department of Psychology, State University of New York at Stony Brook, Stony Brook, NY 11794-2500, USA.
Brain Res. 2009 Mar 19;1261:20-8. doi: 10.1016/j.brainres.2008.12.073. Epub 2009 Jan 15.
It has been suggested that the right inferior frontal gyrus (IFG) plays a critical role in manual response inhibition, although neuroimaging studies of healthy adults have also reported widespread activations in other cortical regions during a variety of response inhibition tasks. We conducted a functional magnetic resonance imaging (fMRI) experiment to examine whether the activation of the IFG is dependent on the type of visuo-motor associations during response inhibition by varying the feature of the stop signal (color vs. orientation) in the stop-signal task. Results from 12 subjects showed that the bilateral ventral posterior IFG, anterior insula, inferior frontal junction (IFJ), middle temporal gyrus (MTG) and fusiform gyrus (FG) are active during response inhibition cued by both color and orientation stop signals. While only the MTG showed differential activity to the two stop signals, both MTG and FG showed significantly stronger activity during successful than unsuccessful stopping of unwanted responses cued by orientation and color, respectively. Our findings suggest that the right ventral posterior IFG may play a more general role in response inhibition regardless of the feature of the visual signal, while successful inhibition may depend on efficient processing of the signal.
有人认为，右侧下额前回（IFG）在手动反应抑制中起着关键作用，尽管健康成年人的神经影像学研究也在各种反应抑制任务中报告了其他皮质区域的广泛激活。我们进行了一项功能磁共振成像（fMRI）实验，通过改变停止信号任务中停止信号的特征（颜色与方向），来检查 IFG 的激活是否取决于反应抑制过程中的视动关联类型。12 名受试者的结果表明，在颜色和方向停止信号提示的反应抑制过程中，双侧腹后 IFG、前岛叶、下额前回交界处（IFJ）、颞中回（MTG）和梭状回（FG）均活跃。虽然只有 MTG 对两种停止信号表现出不同的活性，但 MTG 和 FG 在成功和不成功地抑制由方向和颜色提示的不想要的反应时，分别表现出显著更强的活性。我们的发现表明，右侧腹后 IFG 可能在反应抑制中发挥更一般的作用，而与视觉信号的特征无关，而成功的抑制可能取决于信号的有效处理。
