核糖体辅助蛋白质折叠机制：对核糖体RNA功能的新见解

Mechanism of ribosome assisted protein folding: a new insight into rRNA functions.

作者信息

Samanta Dibyendu, Das Anindita, Bhattacharya Arpita, Basu Arunima, Das Debasis, DasGupta Chanchal

机构信息

Department of Biophysics, Molecular Biology and Genetics, University College of Science, Kolkata 700009, India.

出版信息

Biochem Biophys Res Commun. 2009 Jun 26;384(2):137-40. doi: 10.1016/j.bbrc.2009.04.106. Epub 2009 May 3.

DOI:10.1016/j.bbrc.2009.04.106

PMID:19401192

Abstract

The peptidyl transferase center (PTC), present in the domain V of 23S rRNA of bacteria can act as a general protein folding modulator. Any general function of a nucleic acid polymer (DNA or RNA) is always related to specific sequence/sequences. The ribosome mediated protein folding also involves a specific interaction between the nucleotides of peptidyl transferase center and the amino acids of an unfolded protein. In this article the mechanism of rRNA assisted protein folding and its significance in the light of high resolution crystal structure of ribosome are discussed.

摘要

肽基转移酶中心（PTC）存在于细菌23S rRNA的结构域V中，可作为一种通用的蛋白质折叠调节剂。核酸聚合物（DNA或RNA）的任何通用功能总是与特定序列相关。核糖体介导的蛋白质折叠还涉及肽基转移酶中心的核苷酸与未折叠蛋白质的氨基酸之间的特定相互作用。本文讨论了rRNA辅助蛋白质折叠的机制及其在核糖体高分辨率晶体结构方面的意义。