Grimont Adrien, Bloch-Faure May, El Abida Boutaïna, Crambert Gilles
UPMC Univ. Paris 6/CNRS/INSERM, Centre de Recherche des Cordeliers, Laboratoire de Génomique, Physiologie et Physiopathologie, Rénales, UMRS, 872 Equipe 3 ERL 7226, 15 rue de l'Ecole de Medecine, Paris Cedex, France.
FEBS Lett. 2009 May 19;583(10):1644-8. doi: 10.1016/j.febslet.2009.04.032. Epub 2009 May 3.
Renal functions are regulated by steroid sex hormones, but the exhaustive identification of their receptors along the nephron is still lacking. Here, we have localized all known nuclear or membrane-bound sex hormone receptors and some of their activators along the nephron of male and female mice. Almost all receptors are present in male and female kidney, some of them having very restricted localization. Only one gene tested among 11 (ARA54) exhibits a gender difference in the level of its expression. This first "renal map" of sex steroid receptor expression may serve as a pre-requisite for investigating the role of these hormones on kidney functions.
肾功能受甾体性激素调节，但沿肾单位对其受体的全面鉴定仍很缺乏。在此，我们已在雄性和雌性小鼠的肾单位中定位了所有已知的核或膜结合性激素受体及其一些激活剂。几乎所有受体都存在于雄性和雌性肾脏中，其中一些定位非常局限。在11个测试基因中只有一个（ARA54）在表达水平上存在性别差异。这第一张性类固醇受体表达的“肾脏图谱”可作为研究这些激素对肾功能作用的先决条件。
