Hammond R W, Nemchinov L G
USDA-ARS, BARC-West, Rm.252, Bldg. 011, Beltsville, MD 20705, USA.
Curr Top Microbiol Immunol. 2009;332:79-102. doi: 10.1007/978-3-540-70868-1_5.
Plant-derived biologicals for use in animal health are becoming an increasingly important target for research into alternative, improved methods for disease control. Although there are no commercial products on the market yet, the development and testing of oral, plant-based vaccines is now beyond the proof-of-principle stage. Vaccines, such as those developed for porcine transmissible gastroenteritis virus, have the potential to stimulate both mucosal and systemic, as well as, lactogenic immunity as has already been seen in target animal trials. Plants are a promising production system, but they must compete with existing vaccines and protein production platforms. In addition, regulatory hurdles will need to be overcome, and industry and public acceptance of the technology are important in establishing successful products.
用于动物健康的植物源生物制品正日益成为研究替代的、改进的疾病控制方法的重要目标。尽管目前市场上还没有商业产品,但口服植物疫苗的研发和测试已超越原理验证阶段。像针对猪传染性胃肠炎病毒研发的那些疫苗,有潜力刺激黏膜免疫、全身免疫以及泌乳免疫,这在目标动物试验中已经得到证实。植物是一个很有前景的生产系统,但它们必须与现有的疫苗和蛋白质生产平台展开竞争。此外,还需要克服监管障碍,并且该技术在行业内和公众中的接受度对于成功推出产品至关重要。