Streatfield Stephen J, Howard John A
ProdiGene, Inc., 101 Gateway Boulevard, College Station, TX 77845, USA.
Expert Rev Vaccines. 2003 Dec;2(6):763-75. doi: 10.1586/14760584.2.6.763.
Plants offer an attractive alternative for the production and delivery of subunit vaccines. Various antigens have been expressed at sufficiently high levels in plants to render vaccine development practical. An increasing body of evidence demonstrates that these plant-produced antigens can induce immunogenic responses and confer protection when delivered orally. Plant-based vaccines are relatively inexpensive to produce and production can be rapidly scaled up. There is also the potential for oral delivery of these vaccines, which can dramatically reduce distribution and delivery costs. Here we describe the technology to develop plant-based vaccines, review their advantages and discuss potential roadblocks and concerns over their commercialization. We also speculate on likely future developments with these vaccines and on their potential impact in the realms of human and animal health.
植物为亚单位疫苗的生产和递送提供了一种有吸引力的替代方案。多种抗原已在植物中以足够高的水平表达，使疫苗开发具有可行性。越来越多的证据表明，这些植物产生的抗原经口服递送时可诱导免疫原性反应并提供保护。基于植物的疫苗生产成本相对较低，且生产规模可迅速扩大。这些疫苗还有口服递送的潜力，这可大幅降低分发和递送成本。在此，我们描述开发基于植物的疫苗的技术，综述其优势，并讨论其商业化的潜在障碍和问题。我们还推测这些疫苗未来可能的发展及其在人类和动物健康领域的潜在影响。
