Department of Paediatrics and Adolescent Medicine, The University of Hong Kong, Queen Mary Hospital, Pok Fu Lam, Hong Kong.
BMC Endocr Disord. 2020 Oct 27;20(1):160. doi: 10.1186/s12902-020-00639-9.
Gynaecomastia is a fairly common condition in puberty but is rare in prepubertal boys. While it is necessary to exclude possible endocrinopathay in prepubertal gynaecomastia, medication is an important and potentially reversible cause to consider in new onset gynaecomastia. Isoniazid-induced gynaecomastia has been reported in adult males, but none was reported in the paediatric population and general paediatricians may not be aware of this uncommon side effect.
We hereby report a 11-year-old prepubertal boy who developed gynaecomastia while taking anti-tuberculosis drugs. Investigations excluded endocrinopathies. Gynaecomastia subsided 8 weeks after stopping isoniazid.
This case is the first paediatric case report describing the association of gynaecomastia with isoniazid use. It is important for general paediatricians to recognize this entity, as prompt diagnosis and cessation of the offending drug can lead to resolution of the problem.
男性乳腺发育在青春期较为常见，但在青春期前男孩中很少见。虽然在青春期前男性乳腺发育时必须排除可能的内分泌疾病，但在新发生的乳腺发育中，药物是一个重要且潜在可逆转的原因需要考虑。异烟肼引起的男性乳腺发育已在成年男性中报道，但在儿科人群中尚未报道，一般儿科医生可能不知道这种不常见的副作用。
我们在此报告一例 11 岁青春期前男孩，在服用抗结核药物时出现乳腺发育。检查排除了内分泌疾病。停止使用异烟肼 8 周后，乳腺发育消退。
本病例是首例描述异烟肼使用与乳腺发育相关的儿科病例报告。一般儿科医生认识到这一实体很重要，因为及时诊断和停止使用致病药物可以解决问题。
