Knapp L W, Dawson W D
Department of Biological Sciences, University of South Carolina, Columbia 29208.
J Hered. 1991 Sep-Oct;82(5):431-4. doi: 10.1093/oxfordjournals.jhered.a111120.
Skin from 36 hairless deer mice (Peromyscus maniculatus) homozygous for the recessive hr-2 mutation were analyzed for structural defects in hair and hair loss. Comparison of mutant to wild-type hairs demonstrated characteristic abnormalities in cellular organization, hair shape, length, and fragility. Matings between mutants homozygous for the hr-2 gene and for a second mutation producing hairlessness in deer mice, hr-1, showed that these two genes were nonallelic. Structural abnormalities in hairs associated with the expression of this gene suggest that its primary effect may be on the epidermis.
对36只隐性hr-2突变纯合的无毛鹿鼠（白足鼠）的皮肤进行分析，以研究毛发结构缺陷和脱发情况。将突变型毛发与野生型毛发进行比较，发现细胞组织、毛发形状、长度和脆性存在特征性异常。hr-2基因纯合的突变体与导致鹿鼠无毛的第二个突变hr-1进行交配，结果表明这两个基因是非等位基因。与该基因表达相关的毛发结构异常表明，其主要作用可能在表皮。
