Evans Isabel, Kim Mi-Yeon
MRC Centre for Immune Regulation, Institute for Biomedical Research, Birmingham Medical School, Birmingham, UK.
BMB Rep. 2009 Apr 30;42(4):189-93. doi: 10.5483/bmbrep.2009.42.4.189.
During development lymphoid tissue inducer (LTi) cells are the first hematopoietic cells to enter the secondary lymphoid anlagen and induce lymphoid tissue neogenesis. LTi cells induce lymphoid tissue neogensis by expressing a wide range of proteins that are associated with lymphoid organogenesis. Among these proteins, membrane-bound lymphotoxin (LT) alpha1beta2 has been identified as a critical component to this process. LTalpha1beta2 interacts with the LTbeta-receptor on stromal cells and this interaction induces up-regulation of adhesion molecules and production of chemokines that are necessary for the attraction, retention and organization of other cell types. Constitutive expression of LTalpha1beta2 in adult LTi cells can result in the formation of a lymphoid-like structure called tertiary lymphoid tissue. In this review, we summarize the function of fetal and adult LTi cells and their involvement in secondary and tertiary lymphoid tissue development in murine models.
在发育过程中，淋巴组织诱导细胞（LTi细胞）是最早进入次级淋巴器官原基并诱导淋巴组织新生的造血细胞。LTi细胞通过表达多种与淋巴器官发生相关的蛋白质来诱导淋巴组织新生。在这些蛋白质中，膜结合淋巴毒素（LT）α1β2已被确定为这一过程的关键成分。LTα1β2与基质细胞上的LTβ受体相互作用，这种相互作用诱导黏附分子上调以及趋化因子产生，而趋化因子对于其他细胞类型的吸引、滞留和组织是必需的。成年LTi细胞中LTα1β2的组成型表达可导致形成一种称为三级淋巴组织的类淋巴样结构。在本综述中，我们总结了胎儿和成年LTi细胞的功能及其在小鼠模型中参与次级和三级淋巴组织发育的情况。
