The Burnet Institute, 85 Commercial Rd, Prahran, Victoria 3004, Australia.
Cold Spring Harb Perspect Biol. 2010 May;2(5):a000182. doi: 10.1101/cshperspect.a000182. Epub 2009 Dec 23.
This article focuses on the functions of NF-kappaB that vitally impact lymphocytes and thus adaptive immunity. NF-kappaB has long been known to be essential for many of the responses of mature lymphocytes to invading pathogens. In addition, NF-kappaB has important functions in shaping the immune system so it is able to generate adaptive responses to pathogens. In both contexts, NF-kappaB executes critical cell-autonomous functions within lymphocytes as well as within supportive cells, such as antigen-presenting cells or epithelial cells. It is these aspects of NF-kappaB's physiologic impact that we address in this article.
本文重点介绍 NF-κB 的功能，这些功能对淋巴细胞和适应性免疫至关重要。NF-κB 长期以来一直被认为是成熟淋巴细胞对入侵病原体的许多反应所必需的。此外，NF-κB 在塑造免疫系统方面具有重要功能，使其能够对病原体产生适应性反应。在这两种情况下，NF-κB 在淋巴细胞以及支持细胞（如抗原呈递细胞或上皮细胞）中执行关键的细胞自主功能。本文将讨论 NF-κB 对生理的影响的这些方面。
