Hensley Scott E, Pinto Amelia K, Hickman Heather D, Kastenmayer Robin J, Bennink Jack R, Virgin Herbert W, Yewdell Jonathan W
Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 208921, USA.
J Virol. 2009 Jul;83(14):7357-60. doi: 10.1128/JVI.00623-09. Epub 2009 Apr 29.
Murine norovirus (MNV) is endemic in many research mouse colonies. Although MNV infections are typically asymptomatic in immunocompetent mice, the effects of MNV infection on subsequent experimental viral infections are poorly documented. Here, we infected C57BL/6 mice with MNV and then with either vaccinia virus or influenza A virus. MNV infection had no effect on CD8(+) T-cell or antibody responses to secondary viruses or to secondary virus-induced morbidity or mortality. While our findings suggest that MNV has little influence on host immunity in immunocompetent mice, we would urge caution regarding the potential effects of MNV on immune responses to viruses and other pathogens, which must be determined on a system-by-system basis.
小鼠诺如病毒（MNV）在许多实验小鼠群体中呈地方性流行。虽然MNV感染在免疫功能正常的小鼠中通常无症状，但MNV感染对后续实验性病毒感染的影响鲜有文献记载。在此，我们用MNV感染C57BL/6小鼠，然后再用痘苗病毒或甲型流感病毒感染。MNV感染对CD8(+) T细胞或针对二次感染病毒的抗体反应，以及对二次病毒诱导的发病或死亡均无影响。虽然我们的研究结果表明MNV对免疫功能正常小鼠的宿主免疫影响不大，但我们敦促在考虑MNV对病毒和其他病原体免疫反应的潜在影响时要谨慎，这必须逐个系统地确定。
