Olliaro P, Wells T N C
UNICEF/UNDP/WB/WHO Special Programme for Research and Training in Tropical Diseases, Geneva, Switzerland.
Clin Pharmacol Ther. 2009 Jun;85(6):584-95. doi: 10.1038/clpt.2009.51. Epub 2009 Apr 29.
With the elimination of malaria now considered a realistic goal, it would be useful for scientists and policy makers to have an inventory of the arsenal of antimalarials, current and prospective, that could help make this goal a reality. In order to provide an overview of antimalarial projects in recent clinical development, we review here the global portfolio of antimalarial drugs in clinical phases of development complemented by projects in the preclinical and early discovery phases. The portfolio is discussed in terms of the novelty of the new molecules and their potential health impact in terms of addressing the requirements for the control and eventual eradication of malaria.
随着消除疟疾如今被视为一个现实目标，对科学家和政策制定者而言，拥有一份现有及潜在抗疟药物的清单将很有用，这有助于实现这一目标。为了概述近期临床开发中的抗疟项目，我们在此回顾处于临床开发阶段的抗疟药物的全球组合，并辅以临床前和早期发现阶段的项目。将根据新分子的新颖性及其在满足疟疾控制和最终根除要求方面对健康的潜在影响来讨论这一组合。
