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宿主-病原体相互作用:生物学和公共卫生。

Host-Pathogen Interaction: Biology and Public Health.

机构信息

Escuela Profesional de Medicina, Facultad de Ciencias de la Salud, Universidad Nacional de Moquegua, Moquegua, Peru.

Escuela Profesional de Medicina Humana, Universidad Privada San Juan Bautista, Lima, Peru.

出版信息

Methods Mol Biol. 2024;2751:3-18. doi: 10.1007/978-1-0716-3617-6_1.

DOI:10.1007/978-1-0716-3617-6_1
PMID:38265706
Abstract

Interactions between host and pathogenic microorganisms are common in nature and have a significant impact on host health, often leading to several types of infections. These interactions have evolved as a result of the ongoing battle between the host's defense mechanisms and the pathogens' invasion strategies. In this chapter, we will explore the evolution of host-pathogen interactions, explore their molecular mechanisms, examine the different stages of interaction, and discuss the development of pharmacological treatments. Understanding these interactions is crucial for improving public health, as it enables us to develop effective strategies to prevent and control infectious diseases. By gaining insights into the intricate dynamics between pathogens and their hosts, we can work towards reducing the burden of such diseases on society.

摘要

宿主与致病微生物之间的相互作用在自然界中很常见,对宿主健康有重大影响,通常会导致多种类型的感染。这些相互作用是宿主防御机制和病原体入侵策略之间持续斗争的结果。在本章中,我们将探讨宿主-病原体相互作用的进化,探索其分子机制,研究相互作用的不同阶段,并讨论药理学治疗的发展。了解这些相互作用对于改善公共卫生至关重要,因为它使我们能够制定有效的策略来预防和控制传染病。通过深入了解病原体与其宿主之间的复杂动态,我们可以努力减轻这些疾病对社会的负担。

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Infect Genet Evol. 2023 Mar;108:105405. doi: 10.1016/j.meegid.2023.105405. Epub 2023 Jan 18.
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WHO's Global Tuberculosis Report 2022.世界卫生组织《2022年全球结核病报告》。
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Time trends in tuberculosis mortality across the BRICS: an age-period-cohort analysis for the GBD 2019.金砖国家结核病死亡率的时间趋势:全球疾病负担研究2019的年龄-时期-队列分析
EClinicalMedicine. 2022 Sep 17;53:101646. doi: 10.1016/j.eclinm.2022.101646. eCollection 2022 Nov.
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Immune evasion and provocation by Mycobacterium tuberculosis.结核分枝杆菌的免疫逃逸和免疫激发。
Nat Rev Microbiol. 2022 Dec;20(12):750-766. doi: 10.1038/s41579-022-00763-4. Epub 2022 Jul 25.
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Modeling transmission of SARS-CoV-2 Omicron in China.模拟 SARS-CoV-2 奥密克戎在中国的传播。
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Therapeutic potential of interferon-gamma in tuberculosis.γ-干扰素在结核病中的治疗潜力
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An update on drugs with therapeutic potential for SARS-CoV-2 (COVID-19) treatment.关于具有治疗 SARS-CoV-2(COVID-19)潜力的药物的最新进展。
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