OATP1B3的表达决定了肝细胞癌中钆塞酸二钠的摄取。
Expression of OATP1B3 determines uptake of Gd-EOB-DTPA in hepatocellular carcinoma.
作者信息
Narita Masato, Hatano Etsuro, Arizono Shigeki, Miyagawa-Hayashino Aya, Isoda Hiroyoshi, Kitamura Koji, Taura Kojiro, Yasuchika Kentaro, Nitta Takashi, Ikai Iwao, Uemoto Shinji
机构信息
Department of Surgery, Graduate School of Medicine, Kyoto University, and Department of Diagnostic Pathology, Kyoto University Hospital, 54 Shogoin-Kawahara-cho, Sakyo-ku, Kyoto, 606-8507, Japan.
出版信息
J Gastroenterol. 2009;44(7):793-8. doi: 10.1007/s00535-009-0056-4. Epub 2009 Apr 29.
BACKGROUND
Gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid (Gd-EOB-DTPA) is an MRI contrast agent with perfusion and hepatoselective properties. The purpose of the study was to examine uptake of Gd-EOB-DTPA in the hepatobiliary phase in hepatocellular carcinoma (HCC).
METHODS
A retrospective analysis of 22 patients with HCC who underwent preoperative Gd-EOB-DTPA-enhanced MRI was performed. Enhancement ratios (ERs) and expression levels of the organic anion transporter (OATP) 1B3 protein were examined.
RESULTS
Gd-EOB-DTPA accumulated in the hepatobiliary phase in 6 of the 22 cases. All 6 Gd-EOB-DTPA-positive cases were moderately differentiated HCC, but 11 other moderately differentiated HCCs did not show Gd-EOB-DTPA uptake. Histopathologically, 4 Gd-EOB-DTPA-positive HCCs and 5 Gd-EOB-DTPA-negative HCCs produced bile. HCCs with Gd-EOB-DTPA uptake overexpressed OATP1B3 compared with HCCs without Gd-EOB-DTPA uptake, and OATP1B3 levels were significantly correlated with ERs (r=0.91, P<0.0001).
CONCLUSIONS
Uptake of Gd-EOB-DTPA in HCC is determined by expression of OATP1B3 rather than by tumor differentiation or bile production.
背景
钆塞酸二钠（Gd-EOB-DTPA）是一种具有灌注和肝选择性特性的磁共振成像（MRI）造影剂。本研究的目的是检查钆塞酸二钠在肝细胞癌（HCC）肝胆期的摄取情况。
方法
对22例行术前钆塞酸二钠增强MRI检查的HCC患者进行回顾性分析。检测增强率（ERs）和有机阴离子转运体（OATP）1B3蛋白的表达水平。
结果
22例患者中6例在肝胆期有钆塞酸二钠蓄积。所有6例钆塞酸二钠阳性病例均为中度分化HCC，但其他11例中度分化HCC未显示钆塞酸二钠摄取。组织病理学检查显示，4例钆塞酸二钠阳性HCC和5例钆塞酸二钠阴性HCC产生胆汁。与未摄取钆塞酸二钠的HCC相比，摄取钆塞酸二钠的HCC过度表达OATP1B3，且OATP1B3水平与ERs显著相关（r=0.91，P<0.0001）。
结论
HCC中钆塞酸二钠的摄取取决于OATP1B3的表达，而非肿瘤分化或胆汁生成。
Zotero 插件