Wookey Peter J, Zulli Anthony, Hare David L
Department of Cardiology, University of Melbourne, Austin Health, Austin Campus, Studley Road, Heidelberg, VIC, 3084, Australia.
Histochem Cell Biol. 2009 Aug;132(2):181-9. doi: 10.1007/s00418-009-0600-6. Epub 2009 Apr 29.
Calcitonin receptor-immunoreactive (CTR-ir) endothelial and foam cells were identified in atherosclerotic plaque within the abdominal and thoracic aortas of rabbits fed a cholesterol-supplemented diet. Initially, cells within the endothelial layers of nascent atherosclerotic plaque of arteries were also CD34-positive, a marker of precursor cells of the haematopoietic lineage. In a further rabbit model with more advanced cardiovascular disease, CTR-ir cells were located deeper within the plaque as well as within the endothelial layer overlying the neo-intima. Finally, in the third model, in which the 4-week period on the atherogenic diet was followed by a 12-week period of regression on a normal chow diet, during which serum cholesterol levels returned to the normal range, CTR-ir was markedly reduced in the stabilized fibrous cap of plaque. Thus, the expression of CTR is associated with the early cellular events involved in plaque formation and is down-regulated as stabilisation of plaque progresses in the process of healing.
在喂食高胆固醇饮食的兔子的腹主动脉和胸主动脉粥样硬化斑块中，鉴定出降钙素受体免疫反应性（CTR-ir）内皮细胞和泡沫细胞。最初，动脉新生动脉粥样硬化斑块内皮层中的细胞也是CD34阳性，CD34是造血谱系前体细胞的标志物。在另一个患有更晚期心血管疾病的兔子模型中，CTR-ir细胞位于斑块更深层以及新生内膜上方的内皮层内。最后，在第三个模型中，在致动脉粥样硬化饮食4周后，改为正常饲料饮食12周，在此期间血清胆固醇水平恢复到正常范围，斑块稳定的纤维帽中CTR-ir明显降低。因此，CTR的表达与斑块形成早期的细胞事件相关，并且随着斑块在愈合过程中进展而稳定，其表达下调。
